St. Jude Research
Director: Charles Mullighan, MBBS, MD

Division of Research

Divisional focus

The mission of the Division of Pathology Research is to conduct and support basic and translational research into childhood catastrophic diseases to advance cures through innovations in diagnosis and treatment. The Division encompasses the Center of Excellence for Leukemia Studies (CELS), a St Jude Comprehensive Cancer Center initiative to recruit exceptional faculty who bring conceptual and technical innovation to the study of childhood hematological malignancies. Thus, the Division has a strong focus on understanding the genomic basis and biology of acute leukemia and bone marrow failure, but also brain tumors and immunotherapy.

The Division and CELS oversee substantial core facility resources, including flow cytometry and cell sorting, genomic and single-cell technologies, bioinformatics, metabolomics, and the Advanced Technologies in Genomics Core directed by CELS faculty member Jian Xu, PhD. The Division and its faculty are closely integrated with clinical activities in the Department and shared resources such as the Clinical Biomarkers Laboratory and the Preclinical Testing Program, and they make extensive use of tumor samples and clinical data.

Division resources

Director

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    Charles G. Mullighan, MBBS (Hons), MSc, MD

    Member, St. Jude Faculty

    Senior Deputy Director of Strategic Initiatives, Comprehensive Cancer Center

    Co-Leader, Hematological Malignancies Program

    Medical Director, St. Jude Biorepository

    William E. Evans Endowed Chair

    Charles G. Mullighan, MBBS (Hons), MSc, MD

    Member, St. Jude Faculty

    Senior Deputy Director of Strategic Initiatives, Comprehensive Cancer Center

    Co-Leader, Hematological Malignancies Program

    Medical Director, St. Jude Biorepository

    William E. Evans Endowed Chair

    View Full Profile Explore Charles Mullighan's research

    Affiliations

    Department of Pathology

    Center of Excellence for Leukemia Studies (CELS)

    Hematological Malignancies Program

    St. Jude Graduate School of Biomedical Sciences

    Research Interests

    • The use of integrated genomic and epigenomic approaches to understand the pathogenesis and evolution of acute lymphoblastic leukemia (ALL) and related disorders
    • Defining the interaction of inherited and somatic genetic alterations in leukemogenesis
    • The use of in vitro and in vivo experimental approaches to model genomic abnormalities in leukemogenesis
    • Preclinical therapeutic testing to translate genomic discoveries to new treatment approaches in ALL

    Contact Information

    Charles G. Mullighan, MBBS (Hons), MSc, MD

    Pathology

    MS 342, Room D4047D

    St. Jude Children's Research Hospital

    262 Danny Thomas Place

    Memphis, TN 38105-3678

    (901) 595-3387 (phone)

    (901) 595-5947 (fax)

Faculty

Staff

Kathryn Roberts, PhD
Director – Division of Pathology Research & Center of Excellence for Leukemia Studies

Joy Turner
Manager – Grants & Research Administration

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