St. Jude researchers discover protein that may improve treatment for B-ALL in some patients. Learn more about how this gene’s expression impacts development.
Researchers surveyed the accumulation of toxic proteins in Alzheimer’s models, and discovered that a pathway nicknamed LANDO can limit the protein buildup.
St. Jude scientists found that despite having few mutations, pediatric acute lymphoblastic leukemia does not escape immune detection.
It’s true that adult tumors often have more mutations. Young ALL patients have fewer mutations, but the T cells identify more than two-thirds of them.
This study provided the first detailed genomic and epigenomic map of the IGH-DUX4 rearrangement and suggested the principle a model for the IGH-DUX4 contribution to B-ALL.
T cell exhaustion has proven to be an obstacle for immunotherapy, and investigators hope their basic findings will result in techniques to prevent exhaustion.
The research shows that MAGE genes evolved to protect inherited DNA in men from stress, focusing on a subtype of MAGE genes called MAGE-A.
St. Jude Cloud to accelerate scientific discoveries through access to real-time clinical genome sequencing data
The platform is the first to release prospective, comprehensive clinical whole-genome sequencing data directly from the clinic to the cloud.
Cell Host & Microbe study reveals the nearly 70 proteins the bacteria need to spread and set up shop (colonize) on someone new.
Scheduling delivery of the drug asparaginase with a discontinuous schedule of dexamethasone helps reduce bone damage when the two drugs were given together.
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