-
ALL risk genes give new understanding of leukemia biology
11/25/2019
Researchers find variant common in leukemia that afflicts children and a different leukemia that afflicts adults.
-
Transporter activity depends on its cargo
11/13/2019
Scientists at St. Jude, Weill Cornell Medicine and Columbia University applied single-molecule imaging technologies to explain the activity of specific transporter proteins.
-
Clinical trial lowers ALL relapse rate
10/28/2019
Results are in from a ten-year long clinical trial aimed at preventing relapse in pediatric patients with acute lymphoblastic leukemia.
-
Understanding the control system for regulatory T cells
10/24/2019
MTORC1 may be more than just a molecular pathway. This enzyme may open up new avenues for treating autoimmune diseases and can boost cancer immunotherapy.
-
Exercise may give the brain a boost
10/21/2019
A St. Jude study reveals more about the link between cancer survivors’ physical fitness and their thinking and learning skills.
-
Pharmacogenetics of thiopurine and NUDT15 mutations presented at ASHG
10/18/2019
Researchers have uncovered a relationship between the gene NUDT15 and how thiopurine drugs function. These findings support the use of NUDT15 to guide thiopurine dose to limit treatment related toxicity.
-
Study of telomere length and chronic health conditions presented at ASHG
10/16/2019
St. Jude researchers compared telomere length and age-dependent telomere attrition between childhood cancer survivors and adult control subjects.
-
Do vitamins A and D help the flu vaccine work better? It depends.
10/08/2019
Vitamins A and D can impact how well some children respond to the flu vaccine.
-
St. Jude will help lead national push to create more effective flu vaccines
09/30/2019
Flu is particularly dangerous for some people, including young cancer patients. Here’s the latest on how St. Jude scientists are working to protect them.
-
Childhood cancer treatment can alter Leydig cell function
09/26/2019
Data from the St. Jude Lifetime Cohort Study reveals that current treatment for childhood cancer can affect testosterone production in men.
-
Research reveals structural details of chaperones, critical molecules of the cell
09/20/2019
St. Jude scientists have uncovered a new discovery that reveals how chaperones manage protein folding – which could lead to finding ways to fight disease.
-
Molecule offers focus for taming inflammation
09/12/2019
Chronic inflammation can be deadly. St. Jude researchers have identified a molecule that might lead to new ways to shut it down.
-
How sweet it is: PeCanPIE serves up cancer variants
09/05/2019
Powerful cancer data portal gets an upgrade to identify the genetic culprit for inherited cancer and possibly other genetic diseases.
-
Step aside Marie Kondo, the genome is the real organizational expert
09/04/2019
St. Jude researchers have uncovered the secrets of genome packaging revealed in the 3D genome.
-
Monitoring infection in patients with compromised immune systems
09/03/2019
Digital polymarese chain reaction testing can correlate the amount of virus present in a sample with clinical systems.
-
Taking a wider view reveals potential targets for rhabdoid tumors
08/27/2019
New study finds new rhabdoid tumor targets by identifying which targets these tumors need to survive.
-
Reimagining β-thalassemia and its treatment
08/21/2019
Read the latest on a possible role for rapamycin treatment for b-thalassemia.
-
Image captures ‘streamlined essence of what life entails’
08/19/2019
A St. Jude researcher may have found a possible answer to "one of the most interesting questions in science."
-
Evaluating pediatric cancer through the lens of time
07/29/2019
New study accounts for years of life lost due to cancer. It’s the first time this metric has been used to analyze the childhood cancer burden globally.
-
BRCA2 gene linked to risk of non-Hodgkin lymphoma
07/25/2019
A St. Jude study linked inherited mutations in the BRCA2 gene with a higher risk of non-Hodgkin lymphoma.
-
Studying single cells to understand a type of pediatric brain tumor
07/24/2019
Scientists completed the most in-depth study of medulloblastoma subtypes by studying single cells to help shed light on how cells become cancerous.
-
Learning from rare disorders
07/17/2019
Science Advances highlights St. Jude research into rare inherited Lysosomal disorders caused by mutations in the NEU1 gene.
-
Too little or too much DUX4 is just right
07/11/2019
St. Jude researchers discover protein that may improve treatment for B-ALL in some patients. Learn more about how this gene’s expression impacts development.
-
Scientists follow the data to a surprise
06/27/2019
Researchers surveyed the accumulation of toxic proteins in Alzheimer’s models, and discovered that a pathway nicknamed LANDO can limit the protein buildup.
-
Leukemia mutations: sometimes less is more
06/26/2019
It’s true that adult tumors often have more mutations. Young ALL patients have fewer mutations, but the T cells identify more than two-thirds of them.
-
Researchers discover key genetic trigger that compromises cancer immunotherapy
06/17/2019
T cell exhaustion has proven to be an obstacle for immunotherapy, and investigators hope their basic findings will result in techniques to prevent exhaustion.
-
Study reveals function of cancer-linked MAGE genes
05/29/2019
The research shows that MAGE genes evolved to protect inherited DNA in men from stress, focusing on a subtype of MAGE genes called MAGE-A.
-
Exploring how to get more out of vaccine protection
05/21/2019
Cell Host & Microbe study reveals the nearly 70 proteins the bacteria need to spread and set up shop (colonize) on someone new.
-
Schedule changes improve treatment for acute lymphoblastic leukemia
05/20/2019
Scheduling delivery of the drug asparaginase with a discontinuous schedule of dexamethasone helps reduce bone damage when the two drugs were given together.
-
Flu and strep team up to cause respiratory woes
05/20/2019
Researchers report for the first time that flu sticks to the surface of common respiratory bacteria.
-
First St. Jude director and CEO honored as Giant of Cancer Care
05/10/2019
The Giants of Cancer Care recognition program honors those who advance the field of oncology through research or clinical care.
-
Clues to help cancer survivors with hearing loss ace reading
05/02/2019
Research reveals that survivors with treatment-related severe hearing loss can benefit from personalized reading interventions to focus on reading skills.
-
Researchers reveal key process that regulates cell division
04/30/2019
Read how fluctuations in the intrinsically disordered protein p27 play a key role in regulating cell division.
-
Different immune cell implicated in lupus-related kidney disease
04/29/2019
This work shows for the first time that a type of immune cell called a patrolling monocyte plays a critical role in glomerulonephritis, inflammation of the kidneys
-
Biological machinery of cell’s “executioner” yields secrets of its control
04/25/2019
Discovery of control signals for cell-killing necroptosis promises new treatment pathway for cancers and a broad array of other disorders.
-
St. Jude gene therapy holds promise for treating several diseases, including SCID
04/17/2019
Out of the bubble: Newborns with SCID-X1, also known as "bubble boy" disease, have fully functional immune system for the first time after gene therapy. Learn more about the study.
-
Mechanism revealed that dooms patients with Lou Gehrig’s disease
04/10/2019
Read about how the most common genetic cause of ALS disrupts cell function and how that might lead to new ways to diagnose and treat the disease
-
Inherited gene variation may increase leukemia risk
04/01/2019
The scientists linked inherited variants of the gene USP7 with an increased risk of T-ALL. Changes in this gene are more common in individuals who are African American.
-
Tracking the source of bone cancer mutations
04/01/2019
Read about efforts to improve cure rates for the bone cancer osteosarcoma by tracking how the chemo drug cisplatin may contribute to mutations.
-
Genetic secrets yield treatment clues
03/29/2019
Genomic analysis reveals age-related subsets of acute erythroid leukemia.
-
Finding a 'needle' in a 'haystack' just got easier
03/13/2019
Software helps to reduce error rates in next-generation sequencing data, expanding the clinical potential for the information.
-
How one patient revealed a new route to melanoma
03/04/2019
Read latest on a mutation that drives the most common childhood melanoma plus evidence that patients who carry the alteration may respond to precision medicine.
-
Radiation triples survival for a rare brain tumor
03/01/2019
Treatment success shown in ependymoma clinic trial open at more than 100 locations and with nearly 400 patients.
-
Unraveling the connection between ancestry and cancer
02/21/2019
Scientists found variations in a fourth gene that is linked to a 50% increased ALL risk in Hispanic children. The risk was much lower for non-Hispanic children with the variation.
-
Reducing alert fatigue
02/13/2019
A time-consuming issue for clinicians is assessing drug alerts in EHR systems. Researchers evaluated alerts and found ways to safely reduce alert overrides by 40 percent.
-
Reprogramming immune cells to fight tumors from within
10/19/2018
Scientists have a new strategy to enhance the anti-cancer immune response and slow tumor growth. The goal is to reprogram macrophages to eliminate tumor cells.
-
Rhabdomyosarcoma discoveries move from lab to clinic
08/23/2018
St. Jude scientists have completed the most complete analysis yet of the muscle and soft tissue tumor rhabdomyosarcoma.
-
NCI awards ‘exceptional’ rating to St. Jude Comprehensive Cancer Center
08/22/2018
For the second time in a row, the National Cancer Institute (NCI) has awarded St. Jude the highest possible rank of “exceptional” during renewal of the hospital’s Comprehensive Cancer Center grant.
-
Discovery may help some children avoid bone marrow transplantation
07/26/2018
Researchers have solved a decades-old mystery about which mutations cause a rare, inherited bone marrow disorder. The answer may allow some children to avoid bone marrow transplantation.
-
St. Jude partners with University of Washington to improve knowledge worldwide
07/18/2018
St. Jude and the Institute for Health Metrics and Evaluation at the University of Washington are partnering to advance knowledge and understanding of childhood cancer around the world.
-
Scientists identify a protein complex that shapes T cells’ destiny
07/06/2018
Like a mentor helping medical students choose between specialties, a protein complex helps shape the destiny of developing T cells, according to St. Jude scientists.
-
Genetic counseling suggested for all childhood cancer survivors
06/19/2018
St. Jude has completed the first genome sequencing of cancer survivors and found that 12 percent of childhood cancer survivors may have a higher risk of cancer.
-
Brain tumor subtype discovered that responds to less-aggressive treatment
05/17/2018
St. Jude researchers have discovered that a quarter of medulloblastoma patients have the infant SHH-II subtype. These patients may respond to less aggressive forms of chemotherapy, sparing them a lifetime of side-effects from treatment.
-
WHO expands partnership with St. Jude
05/16/2018
St. Jude is the first WHO Collaborating Centre for Childhood Cancer. Read more about our exciting efforts to increase survival rates of children with pediatric cancer worldwide.
-
A protein ‘gone rogue’ may lead to new cancer treatments
05/16/2018
A protein has been identified that may help researchers target and kill cancer cells more effectively. Learn more about this exciting discovery.
-
Research pinpoints crucial flu mutation
04/24/2018
A mutation has been identified that may help scientists determine how to manufacture drugs to better fight the influenza virus. Learn more about the advances of treating drug resistant viruses.
-
Fourth ALL predisposition gene discovered
04/19/2018
Scientists have discovered a new gene mutation that may help predetermine a child’s risk for developing ALL. Explore the latest breakthroughs.
-
Injured cells and genetic variation may highlight a risk of neurocognitive problems
03/29/2018
St. Jude researchers recently discovered neurocognitive side-effects in patients may stem from leukemia itself, rather than solely from treatment-related causes. Read the latest.
-
Molecule identified that serves as a sentinel for the immune system
03/22/2018
One specific molecule might be the key to preventing infections in pediatric patients. Learn more about this new discovery.
-
How socially connected are cancer survivors? The answer might surprise you.
03/08/2018
As cancer survivorship increases, so do efforts to understand and strengthen social support and advice. Read the latest.
-
A new avenue to prevent hearing loss
03/07/2018
The chemotherapy drug cisplatin may help save a child’s life. But that same medication can also damage a child’s hearing.
-
At the deepest level, children are not just small adults when it comes to cancer
02/28/2018
A comprehensive analysis of the genes and mutations driving childhood cancer reveals just how different the disease is in children and adults.
-
St. Jude Announces Plans for State-of-the-Art Advanced Research Center
02/19/2018
St. Jude announces plans for a new, state-of-the-art advanced research center that will reinforce the scientific efforts of our faculty members. Learn more about this new addition to the St. Jude community.
-
Bringing hope and effective treatment to young refugees with cancer
02/18/2018
The Lebanese refugee crisis offers lessons in how to provide effective treatment for cancer and chronic diseases during emergencies.
-
The chance to earn modest rewards may help get kids moving
02/12/2018
Want young cancer survivors to stay active? Pilot study finds the chance to earn stickers, T-shirts and other rewards helps keep survivors moving.
-
DNA in 3-D reveals a ‘hijacking’ that drives neuroblastoma
01/23/2018
The oncogene c-MYC drives high-risk neuroblastoma in some young cancer patients. The findings lay the groundwork for much needed precision medicines.
-
Improving vaccination rates in hospitals
01/10/2018
A St. Jude quality improvement initiative that greatly increased the employee vaccination rate for pertussis, or whooping cough, offers a model for other health care institutions nationwide.
-
A double whammy for leukemia patients
01/04/2018
St. Jude scientists have discovered new germline variations in a tumor suppressor gene called TP53. Children with these variants are at risk of developing leukemia.