Research

Learn about published research as well as leading-edge basic and translational research initiatives from St. Jude laboratories.

Lando: Star Wars smuggler or possible ally against Alzheimer’s disease?

Mary Powers

High science calls on Star Wars character as a potential ally against Alzheimer’s disease.

SJELIOT clinical trial explores a new approach for recurring and unresponsive medulloblastoma tumors

Gary Bridgman

St. Jude is testing adult cancer drug prexasertib in children with recurrent or refractory medulloblastoma to inhibit checkpoint kinase chk1/2.

Acute lymphoblastic leukemia: collaborations in China showcase the power of global cancer care

Ching-Hon Pui, MD

An agreement between one U.S. hospital and two Chinese hospitals in 1991 has completely changed global pediatric cancer care.

Optimizing leukemia treatment through pharmaceutical science

Mary Relling, PharmD

Effective leukemia treatment is one thing – making sure it’s optimized with minimal implications is another. Read research juggles both to help patients.

Discovering how T cell “exhaustion” is triggered could energize cancer immunotherapy

Ben Youngblood, PhD

Read how the discovery of this gene could change immunotherapy cancer and viral infection treatments.

Enzymes that unlock stress granules, our cells’ biological ‘storm shelters,’ open pathway to treating muscle, brain disorders

Mondira Kundu, MD, PhD

Stress granules form from heat shock to the cell then disappear, but when treated with an inhibitor to the protein ULK, the stress granules persist event after removal of the stress.

Length matters in dipeptide repeat polypeptides – and can be a way to treat ALS

Richard Kriwacki, PhD

Read how the length of these proteins may be an indicator of ALS.

Exploring survivorship: The when and how of treatment strategies matter in adult survivors of childhood ALL

Mike O’Kelly

It used to be just about surviving–now, it’s about treating children with ALL to live long, healthy lives. Learn about ALL survivorship research from ASCO.

Researchers introduce real-time clinical genomics data using St. Jude Cloud platform at 2019 ASCO annual meeting

Elizabeth Whittington

Scott Newman, PhD, shares the release of real-time clinical genomics data through the St. Jude Cloud platform at the 2019 American Society of Clinical Oncology (ASCO) meeting in Chicago, Illinois.

Researchers develop method to dramatically reduce error rate in next-generation sequencing

St. Jude Communications Department

It’s easier to find a needle in a haystack when you take away the hay – read how this research team is reducing gene sequencing errors.