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Bringing Chemistry to Medicine

2020 Chemical Biology and Therapeutics Symposium

Held Friday, September 25, 2020

 
 

The CBT Symposium, held on September 25, brought together leading chemical biologists who are pioneering new synthetic approaches to investigate challenging questions in biology and molecular medicine. 

Hosted by the Department of Chemical Biology & Therapeutics at St. Jude, the symposium offered a broad survey of major advances being made at the interface of chemistry and biology with presentations spanning structure-guided design of smart therapeutics, small molecule-based microarrays and novel chemical library designs, chemical dissection of cell differentiation and death programs, systems-level chemical informatics, and mechanistically informed clinical trials. Beyond present frontiers, the 2020 CBT Symposium explored emerging questions in biomedical sciences that can be uniquely answered by chemical and computational approaches.

Download the abstract booklet

 
 
 
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    Speakers

     
    Ivet Bahar

    Ivet Bahar

    University of Pittsburgh
    UP Drug Discovery Institute

     
    Philip Chamberlain

    Philip Chamberlain

     
    James Chen

    James Chen

    Stanford University

     
    Tarun Kapoor

    Tarun Kapoor

    The Rockefeller University

     
    Angela Koehler

    Angela Koehler

    MIT Biological Engineering

     
    Jun Liu

    Jun Liu

    Johns Hopkins University

     
    Shaomeng Wang

    Shaomeng Wang

    University of Michigan

     

    St. Jude Speakers

     
    Scott Blanchard

    Scott C. Blanchard

     
    Taosheng Chen

    Taosheng Chen

     
    Marcus Fischer

    Marcus Fischer

     
    Richard E. Lee

    Richard E. Lee

     
    Tudor Moldoveanu

    Tudor Moldoveanu

     
    Philip Potter

    Philip M. Potter

     
    Zoran Rankovic

    Zoran Rankovic

     
    Anang Shelat

    Anang Shelat

     

    Agenda

    All times are in Central Time, beginning at 8:45 am CT / 1:45 pm GMT.

    Time Event
    8:45 - 9:00 am Log in
    9:00 - 9:15 am Dr. Aseem Ansari
    Opening Remarks
    Session 1  
    9:20 - 9:35 am Dr. Scott Blanchard
    Bridging the Gap Between Biomolecular Structure and Function Through Single-Molecule Imaging
    9:40 - 9:55 am Dr. Richard Lee
    Antibiotic Discovery at St. Jude
    10:00 - 10:25 am Dr. Jun Liu
    Rapamycin-Inspired Macrocycles as Novel Chemical Probes and Drug Leads
    10:30 - 10:40 am Break
    10:40 - 11:05 am Dr. Angela Koehler
    Attenuating Oncogenic Transcription with Small Molecules
    11:10 - 11:25 am Dr. Taosheng Chen
    Chemical Transcription Modulators of Promiscuous Xenobiotic Receptors
    11:30 - 11:55 am Dr. Shaomeng Wang
    Induced Protein Degradation as a Therapeutic Strategy
    12:00 - 1:00 pm Break
    Session 2  
    1:00 - 1:15 pm Dr. Marcus Fischer
    Bridge Over Troubled Water Networks – Binding and Garfunkel
    1:20 - 1:45 pm Dr. Ivet Bahar
    Network Models in Biology: From Molecular Machinery to Chromosomal Dynamics, to Systems Pharmacology
    1:50 - 2:05 pm Break
    2:05 - 2:10 pm Dr. Aseem Ansari
    Introduction of Dr. Tommaso Cupido
    2:10 - 2:15 pm Dr. Tommaso Cupido
    Introduction of Dr. Tarun Kapoor and Dr. James Chen
    2:15 - 2:40 pm Dr. Tarun Kapoor
    Chemical Biology of Drug Resistance
    2:45 - 3:10 pm Dr. James Chen
    Targeting Colorectal Cancer with Aldehyde Dehydrogenase Inhibitors
    3:15 - 3:30 pm Break
    3:30 - 3:45 pm Dr. Zoran Rankovic
    Targeted Protein Degradation Platform
    3:50 - 4:15 pm Dr. Phil Chamberlain
    History and Future of Thalidomide Analogs in Human Health
    4:20 - 4:55 pm Dr. Anang Shelat and Dr. Phil Potter
    Bromodomain-Selective BETi as Pediatric Anticancer Agents
    5:00 - 5:15 pm Dr. Tudor Moldoveanu
    Probing the Mechanism of Mitochondrial Apoptosis Initiation
    5:20 - 5:30 pm Dr. Aseem Ansari
    Closing Remarks
     
     

    View the Partner Event

    Held on Thursday, September 24, 2020

    Transcription Therapy Symposium

     
     

    The Transcription Therapy Symposium, held on Thursday, September 24, 2020, is a partner event under the overarching theme of Bringing Chemistry to Medicine. This preceding symposium covered scientific advances in chromatin and gene regulation, transcription-targeted therapeutics and more. 

    Learn more about the Transcription Therapy Symposium >>

    Speakers

     
    Aseem Ansari

    Aseem Ansari

    St. Jude Children's Research Hospital

     
    Bobby Arora

    Paramjit (Bobby) Arora

    New York University

     
    Stephen Frye

    Stephen Frye

    University of North Carolina, Chapel Hill

     
    Nathaneal Gray

    ​Nathanael S. Gray

    Stanford University

     
    Anna Mapp

    Anna Mapp

    University of Michigan

     
    Tom Muir

    Tom Muir

    Princeton University

     
    Charles W.M. Roberts

    Charles W.M. Roberts

    St. Jude Children's Research Hospital

     
    Joanna Wysocka

    Joanna Wysocka

    Stanford University

     
    Richard Young

    Richard A. Young

    Whitehead Institute
    Massachusetts Institute of Technology

     
     

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