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Bringing Chemistry to Medicine

2020 Chemical Biology and Therapeutics Symposium

Held Friday, September 25, 2020

 
 

The CBT Symposium, held on September 25, brought together leading chemical biologists who are pioneering new synthetic approaches to investigate challenging questions in biology and molecular medicine. 

Hosted by the Department of Chemical Biology & Therapeutics at St. Jude, the symposium offered a broad survey of major advances being made at the interface of chemistry and biology with presentations spanning structure-guided design of smart therapeutics, small molecule-based microarrays and novel chemical library designs, chemical dissection of cell differentiation and death programs, systems-level chemical informatics, and mechanistically informed clinical trials. Beyond present frontiers, the 2020 CBT Symposium explored emerging questions in biomedical sciences that can be uniquely answered by chemical and computational approaches.

Download the abstract booklet

 
 
 
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Speakers

 
Ivet Bahar

Ivet Bahar

University of Pittsburgh
UP Drug Discovery Institute

 
Philip Chamberlain

Philip Chamberlain

 
James Chen

James Chen

Stanford University

 
Tarun Kapoor

Tarun Kapoor

The Rockefeller University

 
Angela Koehler

Angela Koehler

MIT Biological Engineering

 
Jun Liu

Jun Liu

Johns Hopkins University

 
Shaomeng Wang

Shaomeng Wang

University of Michigan

 

St. Jude Speakers

 
Scott Blanchard

Scott C. Blanchard

 
Taosheng Chen

Taosheng Chen

 
Marcus Fischer

Marcus Fischer

 
Richard E. Lee

Richard E. Lee

 
Tudor Moldoveanu

Tudor Moldoveanu

 
Philip Potter

Philip M. Potter

 
Zoran Rankovic

Zoran Rankovic

 
Anang Shelat

Anang Shelat

 

Agenda

All times are in Central Time, beginning at 8:45 am CT / 1:45 pm GMT.

Time Event
8:45 - 9:00 am Log in
9:00 - 9:15 am Dr. Aseem Ansari
Opening Remarks
Session 1  
9:20 - 9:35 am Dr. Scott Blanchard
Bridging the Gap Between Biomolecular Structure and Function Through Single-Molecule Imaging
9:40 - 9:55 am Dr. Richard Lee
Antibiotic Discovery at St. Jude
10:00 - 10:25 am Dr. Jun Liu
Rapamycin-Inspired Macrocycles as Novel Chemical Probes and Drug Leads
10:30 - 10:40 am Break
10:40 - 11:05 am Dr. Angela Koehler
Attenuating Oncogenic Transcription with Small Molecules
11:10 - 11:25 am Dr. Taosheng Chen
Chemical Transcription Modulators of Promiscuous Xenobiotic Receptors
11:30 - 11:55 am Dr. Shaomeng Wang
Induced Protein Degradation as a Therapeutic Strategy
12:00 - 1:00 pm Break
Session 2  
1:00 - 1:15 pm Dr. Marcus Fischer
Bridge Over Troubled Water Networks – Binding and Garfunkel
1:20 - 1:45 pm Dr. Ivet Bahar
Network Models in Biology: From Molecular Machinery to Chromosomal Dynamics, to Systems Pharmacology
1:50 - 2:05 pm Break
2:05 - 2:10 pm Dr. Aseem Ansari
Introduction of Dr. Tommaso Cupido
2:10 - 2:15 pm Dr. Tommaso Cupido
Introduction of Dr. Tarun Kapoor and Dr. James Chen
2:15 - 2:40 pm Dr. Tarun Kapoor
Chemical Biology of Drug Resistance
2:45 - 3:10 pm Dr. James Chen
Targeting Colorectal Cancer with Aldehyde Dehydrogenase Inhibitors
3:15 - 3:30 pm Break
3:30 - 3:45 pm Dr. Zoran Rankovic
Targeted Protein Degradation Platform
3:50 - 4:15 pm Dr. Phil Chamberlain
History and Future of Thalidomide Analogs in Human Health
4:20 - 4:55 pm Dr. Anang Shelat and Dr. Phil Potter
Bromodomain-Selective BETi as Pediatric Anticancer Agents
5:00 - 5:15 pm Dr. Tudor Moldoveanu
Probing the Mechanism of Mitochondrial Apoptosis Initiation
5:20 - 5:30 pm Dr. Aseem Ansari
Closing Remarks
 
 

View the Partner Event

Held on Thursday, September 24, 2020

Transcription Therapy Symposium

 
 

The Transcription Therapy Symposium, held on Thursday, September 24, 2020, is a partner event under the overarching theme of Bringing Chemistry to Medicine. This preceding symposium covered scientific advances in chromatin and gene regulation, transcription-targeted therapeutics and more. 

Learn more about the Transcription Therapy Symposium >>

Speakers

 
Aseem Ansari

Aseem Ansari

St. Jude Children's Research Hospital

 
Bobby Arora

Paramjit (Bobby) Arora

New York University

 
Stephen Frye

Stephen Frye

University of North Carolina, Chapel Hill

 
Nathaneal Gray

​Nathanael S. Gray

Stanford University

 
Anna Mapp

Anna Mapp

University of Michigan

 
Tom Muir

Tom Muir

Princeton University

 
Charles W.M. Roberts

Charles W.M. Roberts

St. Jude Children's Research Hospital

 
Joanna Wysocka

Joanna Wysocka

Stanford University

 
Richard Young

Richard A. Young

Whitehead Institute
Massachusetts Institute of Technology