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Inspiration4 and St. Jude

A journey to space. A cause for humanity.

Inspiration4 was the world's first all-civilian mission to orbit the Earth. St. Jude is the charitable beneficiary of Inspiration4. Our goal is to raise $200 million for kids with cancer and other life-threatening diseases in honor of this mission.

Donate to St. Jude See Other Ways to Get Involved


Welcome home, Inspiration4 crew!


From cancer patient to astronaut

As a kid, Hayley Arceneaux was treated at St. Jude for osteosarcoma. Now she's a St. Jude physician assistant who had a seat to space on Inspiration4.

Read About Hayley's Journey


See a space chat between the Inspiration4 crew and St. Jude patients

On Sept. 16, the crew talked to a very special group back home on Earth — patients of St. Jude Children's Research Hospital.


Watch Inspiration4 launch and splashdown

See a Replay of the Launch

See a Replay of the Splashdown


Staying here on Earth?

We invite you to be part of our effort to make a better world for the future. Contribute to our fundraising efforts for kids with cancer and other life-threatening diseases, and learn more about this historic spaceflight.

Inspiration4 jacket, hat, and coffee mug.

Show your support for this remarkable milestone with a flight jacket, coffee mug and more. Proceeds benefit St. Jude.

Explore Inspiration4 gear.

Puggle and Huckleberry sit with the plush toys they inspired.

St. Jude facility dogs Puggle and Huckleberry inspired the official zero-gravity indicator the crew had on board. We're sold out, but we can let you know when we have more!

T-shirts, tote bag and phone case from our Amazon store.

Space- and Inspiration4-themed T-shirts, tote bags, pillows, phone cases and more — all to benefit St. Jude kids.

Shop our Amazon store.

Hand holding a coin with the Bitcoin symbol.

Support St. Jude with a donation of Bitcoin, Ethereum, Dogecoin or other cryptocurrencies. 

Give to us with cryptocurrency.

Netflix poster.

Countdown: Inspiration4 Mission to Space is a documentary series that covered the events in near real-time, airing in five parts leading up to and after the mission.

Watch the documentary on Netflix.

Socks and T-shirt with art inspired by St. Jude patient Colton.

Shop our space collection inspired by the artwork of St. Jude patient Colton, or browse through our whole selection. Proceeds benefit St. Jude.

Shop the St. Jude Gift Shop.

St. Jude Mission of a Lifetime podcast logo.

Hear the story of Hayley Arceneaux and the other crew members of Inspiration4 in "St. Jude Mission of a Lifetime."

Listen to our podcast.

St. Jude patient Zahaan playing in his hospital room.

Want to make an immediate impact? Help us meet our fundraising goal by donating to help St. Jude kids.

Donate to Inspiration4.


Meet the Inspiration4 crew

Named for its four-person crew and its mission to inspire support for the lifesaving work of St. Jude, Inspiration4 was commanded by Jared Isaacman. The four crew members represented the mission’s pillars of Leadership, Hope, Prosperity and Generosity.

Headshot of Jared Isaacman.

Jared Isaacman

Commander and benefactor

Leadership seat

Headshot of Hayley Arceneaux.

Hayley Arceneaux

St. Jude cancer survivor

Hope seat

Headshot of Dr. Sian Proctor.

Dr. Sian Proctor

Shift4Shop owner

Prosperity seat

Headshot of Chris Sembroski.

Christopher Sembroski

St. Jude donor

Generosity seat


Sign up for email updates to learn more about how you can help St. Jude continue to save lives.

The Earth from space.
Patient Abraham with his mom.

St. Jude patient Abraham, with his mom.


About St. Jude

St. Jude Children's Research Hospital is leading the way the world understands, treats and defeats childhood cancer and other life-threatening diseases. And families never receive a bill from St. Jude for treatment, travel, housing or food.

St. Jude shares the breakthroughs it makes, and every child saved at St. Jude means doctors and scientists worldwide can use that knowledge to save thousands more children. Learn more.



Jared Isaacman is the founder and CEO of Shift4 Payments, a company he started in 1999 when he was only 16 years old, which today is an industry-leading payments technology company with more than 1,200 employees. Jared is an influential business leader who's been featured by various media outlets and publications. 

An accomplished jet pilot and world-record holder, he's rated to fly commercial and military aircraft. Jared was the commander and benefactor of Inspiration4.

Read more about Jared and his connection to St. Jude.


When Hayley was 10 years old, one of her knees began to ache. Her doctor thought it was just a sprain, but a few months later, tests revealed Hayley suffered from osteosarcoma, a type of bone cancer. Her family turned to St. Jude for her treatment and care, which included chemotherapy and a limb-saving surgery. She's now finished with treatment and thriving.

Hayley obtained an undergraduate degree in Spanish in 2014, and obtained her Physician Assistant (PA) degree in 2016. She now works at St. Jude — the very place that saved her life — as a PA with leukemia and lymphoma patients.

Read more about Hayley.


Dr. Proctor, a 51-year-old entrepreneur, educator, trained pilot and active voice in the space exploration community, was awarded her seat by being selected as the top entrant of an independently-judged online business competition that attracted approximately 200 entries and was conducted by the e-commerce platform Shift4Shop.

Read more about Dr. Proctor.


Chris Sembroski, a 41-year-old aerospace industry employee at Lockheed Martin and United States Air Force veteran, contributed to a special fundraising campaign for St. Jude that offered an Inspiration4 seat to a lucky donor after receiving nearly 72,000 entries. 

Read more about Chris.