Data on elderly patients with esophageal squamous cell carcinoma (ESCC) are limited, and therefore there is not sufficient information to guide treatment decisions for elderly patients with ESCC. This study aims to identify the efficacy of and factors associated with for optimal treatment approaches for elderly patients with ESCC receiving radiotherapy (RT) alone or concurrent chemoradiation (CCRT). The study included 184 I-III elderly ESCC patients (aged ≥70 years) with ESCC treated with oral single-agent CCRT (sCCRT), or double-agents CCRT (dCCRT), or RT alone at a single institution in China. Our results demonstrated that elderly patients receiving CCRT had significantly higher survival benefit than those receiving RT alone, especially those given oral sCCRT. Patients with sCCRT had lower toxicities than those receiving dCCRT, and the toxicity with sCCRT was similar to that with RT alone. GTV dose ≥ 56 Gy and the sequential or simultaneous integrated boost technique were optimal approaches for RT.
Zhao L, Zhou YC, Pan H, Yin Y, Lin SH, Shi M. Radiotherapy alone or concurrent chemoradiation for esophageal squamous cell carcinoma in elderly patients. International Journal of Radiation Oncology, 99(2): E205-E206, 2017.