The Science of Childhood Cancer is an interactive, weekly lecture series designed to engage the scientific community on key questions in pediatric cancer research. The series, hosted by the St. Jude Comprehensive Cancer Center, originally launched in August 2020 and features leading experts across the spectrum of basic, translational, clinical and population science. Explore our library of archived lectures below, and visit our registration page to receive updates about upcoming live events.
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Drivers of transformation in embryonal tumors with multi-layered rosettes (ETMRs)
Annie Huang, MD, PhD, FRCP(C)
Pediatric Neuro-oncologist, Pediatric Brain Tumor Program, Division of Hematology Oncology, Senior Scientist, Program in Cell Biology – Labatt Brain Tumor Research Centre
Canada Research Chair in Rare Childhood Brain Tumors, Professor of Paediatrics, Medical Biophysics, Lab Medicine & Pathobiology; Associate Chair (Research), Department of Pediatrics – SickKids Hospital, University of Toronto
Lead investigator – The Rare Brain Tumor Consortium
Epigenetic and 3D genome alteration in cancer
Feng Yue, PhD
Director, Center for Cancer Genomics – Robert H. Lurie Comprehensive Cancer Center
Duane and Susan Burnham Professor for Molecular Medicine, Professor, Department of Biochemistry and Molecular Genetics – Northwestern University Feinberg School of Medicine
Opportunities and challenges in pediatric oncology drug development: Lessons learned from the biopharmaceutical industry
Sam Blackman, MD, PhD
Head of Research & Development – Day One Biopharmaceuticals
Genomic analysis of osteosarcoma: Making sense of a complex genome to advance translational research and targeted therapy
Alejandro Sweet-Cordero, MD
Chief, Division of Pediatric Oncology –
University of California-San Francisco
The financial burden of surviving childhood cancer
Paul Nathan, MD, MSc
Head, Solid Tumor Section & Director, AfterCare Program, Division of Hematology/Oncology – The Hospital for Sick Children
Professor, Pediatrics and Health Policy, Management & Evaluation – University of Toronto
Advancing outcomes for patients with neuroblastoma
Sara Federico, MD
Member – Department of Oncology, St. Jude Children's Research Hospital
Childhood neuroblastoma: evolution and malignant progression
Frank Westermann, MD
Head of Division – German Cancer Research Center (DKFZ), Heidelberg, Germany
Head of Section Embryonal Tumors – Hopp Children’s Cancer Center (KiTZ), Heidelberg, Germany
Pushing for new biology and cancer therapies in rhabdomyosarcoma
David Langenau, PhD
Professor of Pathology – Harvard Medical School
Faculty – Mass General Cancer Center and Pathology
Sounding an alarm: Innate immunity makes cancer immunogenic
Judy Lieberman, MD, PhD
Endowed Chair in Cellular and Molecular Medicine – Program in Cellular and Molecular Medicine and Boston Children's Hospital
Professor of Pediatrics – Harvard Medical School
Translating the self/nonself discrimination problem in cancer
Benjamin Greenbaum, PhD
Associate Attending & Program Leader in Computational Immuno-oncology – Memorial Sloan Kettering Cancer Center
Associate Professor, Physiology, Biophysics & Systems Biology – Weill Cornell Medicine
Liquid biopsies in pediatric solid tumors: refining treatment and studying tumor evolution
Brian Crompton, MD
Dana-Farber/Boston Children's Cancer and Blood Disorders Center
Co-Director for Research, Pediatric Solid Tumor Program, Assistant Professor of Pediatrics – Harvard Medical School
Associate Member – Broad Institute of Harvard and MIT
Lecture not recorded
Novel venetoclax combinations for relapsed pediatric leukemia
Seth Karol, MD
Associate Member – Leukemia & Lymphoma Division, Department of Oncology, St. Jude Children's Research Hospital
Cell therapies for pediatric solid tumors – Beyond conventional CAR-T
Catherine Bollard, MBChB, MD
Interim Chief Academic Officer, Director – Center for Cancer & Immunology Research
Director – Program for Cell Enhancement & Technologies for Immunotherapy
Professor of Pediatrics and of Microbiology, Immunology & Tropical Medicine – Children's National Hospital, Children's National Research Institute, The George Washington University School of Medicine & Health ServicesLecture not recorded
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Special Event:
New BIG data resources on St Jude Cloud: The Pediatric Cancer Knowledgebase (PeCanV2) and Survivorship Portal
This presentation will include an overview followed by live demo of two newly released BIG data resources on St Jude Cloud, a Cloud-based pediatric cancer data sharing ecosystem:
- PeCanV2 for ontology-driven exploration of interesting patterns of genomic landscapes, mutational signatures, transcriptomics, and histology slides from >9,000 pediatric cancer samples; and
- A survivorship portal for on-the-fly analysis of 1,621 clinical variables related to demographics, cancer diagnosis/treatment, laboratory measurements and late effects, 3,328 polygenic risk scores, with 100M genetic variants from 7,169 long-term survivors enrolled in St. Jude Lifetime (SJLIFE) and Childhood Cancer Survivorship Study (CCSS).
The panel of St. Jude experts:
Jinghui Zhang, PhD
Member and Chair
Department of Computational Biology
St. Jude Children's Research Hospital
Clay McLeod
Director of Product Development and Engineering
Computational Biology
St. Jude Children's Research Hospital
Kirsten K. Ness, PT, PhD, FAPTA
Member
Epidemiology and Cancer Control
St. Jude Children's Research Hospital
Xin Zhou, PhD
Assistant member
Computational Biology
St. Jude Children's Research Hospital
Hereditary Predisposition to Cancer: At the Tip of the Iceberg
Kim E. Nichols, MD
Member, Department of Oncology
Director, Division of Cancer Predisposition
St. Jude Children's Research Hospital
New mechanistic insights into the development of pediatric myeloid tumors
Jeffery M. Klco, MD, PhD
Associate Member, Department of Pathology
Director, Division of Hematopathology and Molecular Pathology
Rewiring Cancer Drivers to Activate Apoptosis
Gerald Crabtree, MD
David Korn Professor of Pathology
Professor, Developmental Biology
Stanford University
Emerging Therapies for Pediatric Leukemia
Sarah K Tasian, MD
Associate Professor of Pediatrics, University of Pennsylvania School of Medicine
Chief, Hematologic Malignancies Program, Children’s Hospital of Philadelphia
Lineage Histories and Function in the Hematopoietic System
Fernando Camargo, PhD
Professor
Stem Cell Program, Children's Hospital Boston
Department of Stem Cell and Regenerative Biology, Harvard UniversityLecture not recorded.
Evolution of Our Understanding of WNT and SHH Medulloblastoma
Amar Gajjar, MD
Member and Chair, Department of Pediatric MedicineCo-Chair, Department of Oncology
Director, Neuro-Oncology Division
Co-Leader, Neurobiology & Brain Tumor Program
Scott and Tracie Hamilton Endowed Chair in Brain Tumor Research
St. Jude Children's Research Hospital
Harnessing Implementation Science to Improve Outcomes for Children with Cancer who Develop Critical Illness
Asya Agulnik, MD, MPH
Associate Member, St. Jude Faculty
Director, Global Critical Care Program, St. Jude Global
Director, Euro Regional Program, St. Jude Global
Dr. Sara Federico's presentation, originally scheduled for April 13, was postponed.
Mechanisms of chromatin regulation by EWS fusion proteins
Miguel N. Rivera, MD
Associate Professor, Pathology, Harvard Medical School
Investigator, Center for Cancer Research, Massachusetts General Hospital
HOX-high Leukemias in Childhood
Kathrin M. Bernt, MD
Assistant Professor of Pediatrics
Attending Physician, Division of Pediatric Oncology, The Children's Hospital of Philadelphia
Member, University of Pennsylvania Abramson Cancer Center (NCI designated)
CAR T-cells for T-cell Malignancies: Proving and Improving
Maksim Mamonkin, PhD
Assistant Professor
Pathology & Immunology
Center for Cell and Gene Therapy
Baylor College of Medicine
What will it take to make CARTs effective for pediatric brain tumors?
Giedre Krenciute, PhD
Assistant Member
Department of Bone Marrow Transplantation & Cellular Therapy
Comprehensive Cancer Center
St Jude Children’s Research Hospital
Dissecting Adult and Pediatric Gliomas by Single-cell Genomics
Mario Suva, MD, PhD
Associate Professor of Pathology, Mass General Hospital and Harvard Medical School
Institute Member, Broad Institute of MIT and Harvard
Lecture not recorded
Psychological and Biobehavioral Health Outcomes in Survivors of Childhood Cancer
Tara M. Brinkman, PhD
Associate Member
Department of Epidemiology and Cancer Control
Department of Psychology
St. Jude Children’s Research Hospital
Building a Mind for Cancer
Trey Ideker, PhD
Professor of Genetics, Department of Medicine, UC San DiegoLecture not recorded
The Dutch Childhood Cancer Survivor Study LATER; Results and Implications
Leontien CM Kremer, MD, PhD
Professor Survivorship Childhood Cancer, Princess Maxima Center for Pediatric Oncology, Utrecht, The NetherlandsLecture not recorded
Clonal Hematopoiesis and the Origins of Blood Cancers
Benjamin Ebert, MD, PhD
George P. Canellos, M.D. and Jean S. Canellos Professor of Medicine – Harvard Medical School
Chair of Medical Oncology – Dana Farber Cancer Institute
Investigator – Howard Hughes Medical Institute
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Prognostic Significance of Aberrant Body Composition and Musculoskeletal Deficits in Childhood Cancer Survivors
Sogol Mostoufi-Moab, MD, MSCE
Associate Professor
Perelman School of Medicine
University of Pennsylvania
Richard and Sheila Sanford Endowed Chair in Pediatric Oncology
Children’s Hospital of Philadelphia
Co-opting the TCR Machinery to Enhance CAR T Cell Efficacy and Specificity
Robbie Majzner, MD
Assistant Professor of Pediatrics
Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine
Stanford University
The Evolution of Pediatric Gliomas
Pratiti (Mimi) Bandopadhayay, MBBS, PhD
Assistant Professor of Pediatrics
Dana-Farber/Boston Children’s Cancer and Blood Disorders Center
Histone Variants and Chaperones in Shaping Chromatin and Cell Fate
Dr. Geneviève Almouzni
Head of the Chromatin Dynamics team
Institut Curie - Research Center / CNRSLecture not recorded
The Lifetime Impact of Childhood Cancer and Cancer Therapy: The Childhood Cancer Survivor Study
Greg Armstrong, MD, MSCE
Full Member, Department of Epidemiology and Cancer Control
St. Jude Children's Research Hospital
Therapeutic Targeting of Epigenetic Modifiers in Leukemia
Jolanta Grembecka, PhD
Professor of Pathology
University of MichiganLecture not recorded
Curing Childhood Cancer and Curing Children with Cancer – Strategies to Address Global Inequities in Childhood Cancer Care and Control
Carlos Rodriguez-Galindo, MD
Executive Vice President
Director, St. Jude Global
Chair, Department of Global Pediatric Medicine
St. Jude Children's Research Hospital
Targeting Bcl-2 Family Proteins in Leukemia
Marina Konopleva, MD, PhD
Leader of the Leukemia Program; Professor of Hematology-Oncology and Co-DirectorTranslational Blood Cancer Institute
Albert Einstein College of Medicine and Professor of Medicine
University of Texas MD Anderson Cancer Center
Pediatric Oncology Drug Development – Learning from Past Successes to Create a Better Future
Malcolm A. Smith, MD, PhD
Associate Branch Chief, Pediatrics
Cancer Therapy Evaluation Program (CTEP)
National Cancer Institute (NCI)
From Bedside to Bench and Back to Bedside: Travels in the Systems Biology of GVHD
Leslie S. Kean, MD, PhD
Director, Stem Cell Transplantation Program
Division of Hematology/Oncology, Boston Children’s Hospital
Department of Pediatric Oncology, Dana-Farber Cancer Institute
Robert A. Stranahan Professor of Pediatrics, Harvard Medical School
The Li-Fraumeni Syndrome Genomic Landscape: Harnessing p53 for Clinical Utility
David Malkin, MD, FRCPC
Senior Staff Oncologist & Senior Scientist
The Hospital for Sick Children
Professor, Departments of Pediatrics and Medical Biophysics
University of TorontoLecture not recorded.
Designing and Developing Pediatric Cancer-Specific Immunotherapies
John M. Maris, MD
Giulio D'Angio Professor of Pediatric Oncology
Perelman School of Medicine at the University of Pennsylvania
A New Model of Oncogenic Kinase Signaling via Membraneless Cytoplasmic Protein Granules
Trever Bivona, MD, PhD
Professor of Medicine, Hematology/Oncology
University of California, San Francisco
Oncohistones Organize Chromatin Architecture to Regulate Developmental Programs
Nada Jabado, MD, PhD
Professor of Pediatrics and Human Genetics
McGill University
Identifying Epigenetic Mechanisms of Failure in T Cell-Based Immunotherapy
Benjamin Youngblood, PhD
Associate Member
St Jude Children’s Research Hospital
Presented August 18, 2022.Lecture not recorded.
Updates with Engineered T Cells
Carl H. June, MD
Director, Center for Cellular Immunotherapies
Professor of Pathology and Laboratory Medicine
Director, Parker Institute for Cancer Immunotherapy
Perelman School of Medicine at the University of Pennsylvania -
The Conformational Landscape of Protein Kinases in Physiology and Disease
Charalampos Kalodimos, PhD
Member, St. Jude Faculty
Chair, Structural Biology Department
Joseph Simone Endowed Chair in Basic Research
St. Jude Children's Research Hospital
Genetic Susceptibility to Subsequent Neoplasms Following Childhood Cancer
Lindsay M. Morton, PhD
Senior Investigator & Deputy Branch Chief, Radiation Epidemiology Branch
Head, Cancer Survivorship Research Unit
Division of Cancer Epidemiology and Genetics, National Cancer Institute
Unraveling the Heterogeneity of Acute Lymphoblastic Leukemia Through the Lens of Pharmacogenomics
Jun J. Yang, PhD
Member and Vice Chair, Division of Pharmaceutical Sciences
Department of Pharmacy and Pharmaceutical Sciences
St. Jude Children's Research Hospital
Identify Novel Therapeutic Opportunities in Pediatric Cancers Using High-Resolution CRISPR Tiling Scans
David Chen, PhD
Associate Professor, Systems Biology , City of Hope Cancer Center
Reading Epigenetic Landscape: New Mechanisms and Therapeutic Opportunities
Liling Wan, PhD
Assistant Professor, Department of Cancer Biology
Penn Epigenetics Institute
Perelman School of Medicine, University of PennsylvaniaLecture not recorded
Disrupted Development in Pediatric High-Grade Glioma
Suzanne J. Baker, PhD
St. Jude Children's Research HospitalLecture not recorded
What Can We Learn From GWAS Data? Genetic Heterogeneity and Rare Variant Hypothesis of Cancer Risk
Yutaka Yasui, PhD
Member, Epidemiology and Cancer Control
St. Jude Children's Research Hospital
Pathobiology of asparaginase resistance
Alejandro Gutierrez, MD
Associate Professor of Pediatrics, Boston Children’s Hospital
Dana-Farber Cancer Institute.Lecture not recorded
Learning From Children: Designing Better Clinical Trials with Their Data
Katherine A. Janeway, MD, MMSc
Associate Professor of Pediatrics, Harvard Medical School
Senior Physician, Dana-Farber / Boston Children's Cancer and Blood Disorders Center
Director, Clinical Genomics, Dana-Farber Cancer Institute
Targeting Hidden Drivers Toward Precision Oncology
Jiyang Yu, PhD
Associate Member
Department of Computational Biology
St. Jude Children's Research Hospital
Mapping Childhood Brain Tumor Profiles Onto Normal Development Identifies Novel Therapeutic Vulnerabilities
Prof. Dr. Stefan M. Pfister
Director Preclinical Program, Hopp Children's Cancer Center Heidelberg (KiTZ)
Head, Division of Pediatric Neurooncology, DKFZ
Deputy Head, KiTZ Clinical Trial Unit (ZIPO) and Pediatric Brain Tumors, Heidelberg University Hospital
Functional Genomics of T-Cell Metabolism and Immuno-oncology
Hongbo Chi, PhD
Member and Robert G. Webster Endowed Chair in Immunology, St. Jude Children's Research Hospital
Discovering and Targeting Neuroblastoma Vulnerabilities: ALK Inhibition as a Paradigm
Yaël Mossé, MD
Children's Hospital of Philadelphia
Human Metabolic Outliers
Ralph J. DeBerardinis, MD, PhD
HHMI Investigator and Professor
Children’s Medical Center Research Institute at UT SouthwesternLecture not archived
Clonal Evolution and Somatic Reversion in Genetic Predisposition to TP53-Mutated MDS
Akiko Shimamura, MD, PhD
Professor of Pediatrics, Harvard Medical School
Samuel E. Lux IV Chair in Hematology Oncology
Director, Bone Marrow Failure and MDS Program
Dana Farber/Boston Children’s Cancer and Blood Disorders Center
Secondary Breast Cancer: A Paradigm for Survivorship Research
Kevin Oeffinger, MD
Director
DCI Center for Onco-Primary Care
Duke University -
Deconvoluting the Origins of Acute Leukemia
Charles G. Mullighan, MBBS (Hons), MSc, MD
Member, Pathology
Deputy Director, Comprehensive Cancer Center
St. Jude Children’s Research Hospital
Identification of Biomarkers, Models and Targets to Improve Outcomes and Precision Approaches for Neuroblastoma
Meredith Irwin, MD
Paediatrician-in-Chief
The Hospital for Sick Children
Chair, Department of Paediatrics; Professor, Departments of Paediatrics; Medical Biophysics; Laboratory Medicine & Pathobiology
University of Toronto
Modulation of the Activity of the Dominant Oncogene EWS-FLI1 by Germline Polymorphisms and Cohesin Mutations
Olivier Delattre, MD, PhD
Inserm Research Director
Head of Cancer, Heterogeneity, Instability and Plasticity Department
Head of the Pediatric Oncology Center
Institut Curie, Paris, France
The Role of Survivorship Research in Advancing Childhood Cancer Care and Quality of Survival
Melissa M. Hudson, MD
Director, Cancer Survivorship Division
St. Jude Children’s Research Hospital
Deciphering Somatic Evolution with Single-Cell Multi-Omics
Dan A. Landau, MD, PhD
Associate Professor of Medicine, Division of Hematology and Medical Oncology
Associate Professor of Physiology and Biophysics
Weill Cornell Medical College
Core Member
New York Genome CenterLecture not archived.
The Biology, Diagnosis, and Management of T-Cell Acute Lymphoblastic Leukemia and Lymphoma
David T. Teachey, MD
Associate Professor of Pediatrics
Division of Oncology
The Children’s Hospital of Philadelphia
University of Pennsylvania
Perelman School of Medicine
Sunlight and Skin: Lessons for Melanoma Therapeutics From Its Unique Pathogenesis
David E. Fisher, MD, PhD
Professor of Dermatology and Pediatrics
Chair, Dept of Dermatology
Mass General Hospital & Harvard Medical School
Influence of Metabolism on Cancer Progression
Matt Vander Heiden, MD, PhD
Director, Koch Institute
Lester Wolfe Professor in Molecular Biology
Koch Institute for Integrative Cancer Research at MIT
Epigenetic Mechanisms of Tumorigenesis
Bradley Bernstein, MD, PhD
Chair, Department of Cancer Biology
Dana-Farber Cancer Institute
Institute Member
Broad Institute of Harvard and MIT
Rising Stars of Cancer Research
Chimeric Antigen Receptor-Redirected Macrophages for the Treatment of Solid Tumors
Saar Gill, MBBS, PhD, FRACP
Associate Professor of Medicine
Scientific Co-Director, Cell Therapy and Transplantation
University of Pennsylvania Perelman School of Medicine
Rising Stars of Cancer Research
Engineering Next-Generation CAR-T Cells for Cancer Immunotherapy
Yvonne Y. Chen, PhD
Associate Professor of Microbiology, Immunology & Molecular Genetics
University of California, Los AngelesLecture not archived.
What Will it Take To Cure Every Child with Acute Lymphoblastic Leukemia?
Mignon Loh, MD
Professor of Pediatrics
Benioff Chair of Children’s Health
Deborah and Arthur Ablin Endowed Professor of Pediatric Molecular Oncology
Chair, ALL Committee, Children’s Oncology Group
Benioff Children’s Hospital, UCSF, San Francisco, CA
CAR T Cell Therapies for Childhood Cancer, the University College London Experience
Martin Pule, MB, FRCPath
Senior Lecturer in Haematology
University College London
Interventions to Prevent or Remediate Frailty in Childhood Cancer Survivors
Kirsten K. Ness, PT, PhD, FAPTA
Member, Epidemiology and Cancer Control
St. Jude Children’s Research Hospital
Rising Stars of Cancer Research
Tailoring Medulloblastoma Therapy to Fit the Evolving Molecular Landscape
Giles Robinson, MD
Associate Member, Oncology Department
St. Jude Children’s Research Hospital
Rising Stars of Cancer Research
Developmental Pathways, Plasticity and Novel Treatment Opportunities in Pediatric High-Grade Brain Tumors
Mariella Filbin, MD, PhD
Attending Physician in Pediatric Hematology/Oncology
Assistant Professor of Pediatrics, Harvard Medical School
Co-Director for Research, Pediatric Neuro-Oncology Program
Dana-Farber Cancer Institute
Boston Children’s Cancer and Blood Disorder CenterLecture not archived.
Persister Act: Near-Death Experiences in Cancer Cells
Douglas R. Green, PhD
Chair, Immunology Department
Co-Leader, Cancer Biology Program
Peter C. Doherty Endowed Chair of Immunology
St. Jude Children's Research HospitalLecture not yet archived.
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Genomic Variants in Pediatric Cancer: Landscape, Precision Oncology, and Data Sharing Ecosystem
Jinghui Zhang, PhD
Chair, Department of Computational Biology
St. Jude Endowed Chair in Bioinformatics
St. Jude Children’s Research Hospital
Original lecture date: January 28
Will We Ever Cure Cancer?
Richard Gilbertson, MD, PhD
Li Ka Shing Chair of Oncology
Head, Department of Oncology
Director, Cancer Research UK Major Centre
University of Cambridge, England
Original lecture date: February 4
Chromatin Complexes as Therapeutic Opportunities in Cancer
Scott Armstrong, MD, PhD
President, Dana-Farber/Boston Children’s Cancer and Blood Disorders Center
Chair, Department of Pediatric Oncology
Dana-Farber Cancer Institute
David G. Nathan Professor of Pediatrics
Harvard Medical School
Original lecture date: February 11
Financial Hardship After Childhood Cancer
Robin Yabroff, PhD, MBA
Scientific Vice President, Health Services Research
American Cancer Society
Original lecture date: February 18
Mechanisms of Leukemogenesis in Children with Down Syndrome
John Crispino, PhD, MBA
Director, Division of Experimental Hematology
The Wall Street Committee Endowed Chair
Department of Hematology
St. Jude Children’s Research Hospital
Original lecture date: February 25
Therapeutic Targeting of Self-Renewal of Medulloblastoma Stem Cells: Strategies for Blocking Recurrence
Sheila Singh, MD, PhD, FRCS(C)
Pediatric Neurosurgeon, McMaster Children's Hospital
Professor of Surgery, McMaster University
Principal Investigator, Stem Cell and Cancer Research Institute, McMaster University
Senior Canada Research Chair in Human Cancer Stem Cell Biology
University Scholar, Chair, McMaster College of Health Inventors
Original lecture date: March 4
Single Cell Atlases as Roadmaps in Pediatric Cancer
Aviv Regev, PhD
Head of Research and Early Development
Genentech
Original lecture date: March 11
Successes and Challenges in Pediatric Cancer: The COG Perspective
Douglas S. Hawkins, MD
Chair of Children's Oncology Group
Professor of Pediatrics
University of Washington School of Medicine
Seattle Children’s Hospital
Original lecture date: March 18
Pediatric High-grade Glioma – Novel Drivers Define a Spectrum of New Tumor Subgroups
David T.W. Jones, PhD
Group Leader, 'Pediatric Glioma Research'
Hopp Children’s Cancer Center (KiTZ)
German Cancer Research Center (DKFZ)
Original lecture date: March 25
A Role for Metabolism in Cancer Development and Progression
Karen Vousden, PhD
Senior Group Leader
The Francis Crick Institute
Original lecture date: April 1Lecture not archived
Identifying Strategies to Improve HPV Vaccination Among Childhood Cancer Survivors
Anne Kirchhoff, PhD, MPH
Associate Professor, Pediatrics
Investigator
University of Utah/Huntsman Cancer Institute
Original lecture date: April 8
Data Science Approaches to GPCR Signaling and Personalized Medicine
Madan Babu, PhD, FRSC
Endowed Chair in Biological Data Science
Director, Center of Excellence for Data Driven Discovery
Department of Structural Biology
St. Jude Children’s Research Hospital
Original lecture date: April 15
Genetic and Epigenetic Approaches Towards Understanding Risk of Chronic Health Conditions Among Survivors of Childhood Cancer
Zhaoming Wang, PhD
Department of Epidemiology and Cancer Control
Department of Computational Biology
St. Jude Children’s Research Hospital
Original lecture date: April 22
A First-generation Pediatric Cancer Dependency Map
Kimberly Stegmaier, MD
Professor of Pediatrics, Harvard Medical School
Ted Williams Chair and Vice Chair of Pediatric Oncology Research, Dana-Farber Cancer Institute
Institute Member, Broad Institute of Harvard and MIT
Original lecture date: April 29, 2021
Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Cancer
Cigall Kadoch, PhD
Associate Professor, Department of Pediatric Oncology
Dana-Farber Cancer Institute and Harvard Medical School
Institute Member and Epigenomics Program Co-Director, Broad Institute
Original lecture date: May 6, 2021 -
CAR T Cells: On the Road to Synthetic Immunity
Michel Sadelain, MD, PhD
Director, Center for Cell Engineering
Stephen and Barbara Friedman Chair
Member, Immunology Program
Member, Departments of Medicine and Pediatrics
Memorial Sloan-Kettering Cancer Center
Original lecture date: August 13
Chromatin Remodeler Mutations in Cancer: Mechanisms and Therapeutic Vulnerabilities
Charles W.M. Roberts, MD, PhD
Member, St. Jude Faculty
Executive Vice President
Director, Comprehensive Cancer Center
Director, Division of Molecular Oncology
Department of Oncology
St. Jude Children's Research Hospital
Original lecture date: August 20
The Future of CAR T Cells for Hematologic Malignancies: Beyond Antigen Targeting
Terry J. Fry, MD
Professor of Pediatrics, Hematology and Immunology
Co-Director, Human Immunology and Immunotherapy Initiative and Director of Cancer Immunotherapy
University of Colorado School of Medicine
Robert and Kathleen Clark Endowed Chair in Pediatric Cancer Therapeutics
Children’s Hospital Colorado, Center for Cancer and Blood Disorders
Original lecture date: August 27
Phase Separation in Gene Transcription: From the Nucleolus to Aberrant Transcription in Leukemia
Richard W. Kriwacki, PhD
Co-Leader, Cancer Biology Program
Department of Structural Biology
St. Jude Children's Research Hospital
Original lecture date: September 3
Late Effects Among Survivors of Blood or Marrow Transplantation
Smita Bhatia, MD, MPH
Director, Institute for Cancer Outcomes and Survivorship
Gay and Bew White Endowed Chair in Pediatric Oncology
Professor and Vice Chair, Dept. of Pediatrics
School of Medicine, University of Alabama at Birmingham
Original lecture date: September 10
Advancing CAR T Cells for the Treatment of Glioblastoma: Progress and Challenges
Christine Brown, PhD
Heritage Provider Network Professor of Immunotherapy
Deputy Director, T Cell Therapeutics Research Laboratory
City of Hope
Original lecture date: September 17Lecture not archived.
Cognitive Outcomes of Childhood Cancer: Neurophysiology, Biomarkers and Interventions
Kevin R. Krull, PhD
Endowed Chair, Cancer Survivorship
Faculty Member, Departments of Epidemiology and Cancer Control, and Psychology
St. Jude Children's Research Hospital
Original lecture date: September 24
3D Chromosomal Organization in Pediatric Leukemia: Impact for Drug Response and Disease Progression
Iannis Aifantis, PhD
Professor and Chair
Department of Pathology and Perlmutter Cancer Center
NYU Grossman School of Medicine
Original lecture date: October 1
Medulloblastomics 2020: Biological & Clinical Insights From 1,000s of Patients
Paul A. Northcott, PhD
Associate Faculty Member, Department of Developmental Neurobiology
Division of Brain Tumor Research
St. Jude Children's Research Hospital
Original lecture date: October 8
CAR T Cells for Pediatric Cancers: Progress and Challenges
Crystal Mackall, MD
Ernest and Amelia Gallo Family Professor of Pediatrics and Internal Medicine
Founding Director, Stanford Center for Cancer Cell Therapy
Director, Parker Institute for Cancer Immunotherapy at Stanford
Associate Director, Stanford Cancer Institute
Leader, Cancer Immunology and Immunotherapy Program
Director, Cancer Immunotherapy Program
Department of Pediatrics - Hematology & Oncology
Department of Medicine - Blood & Marrow Transplantation
Stanford University
Original lecture date: October 15
Partitioning of Cancer Therapeutics in Nuclear Condensates
Richard A. Young, PhD
Professor, Department of Biology
Member, Whitehead Institute
Massachusetts Institute of Technology (MIT)Isaac A. Klein, MD, PhD
Dana-Farber Cancer Institute
Whitehead Institute
Original lecture date: October 22
Harnessing Lineage Plasticity for the Treatment of Neuroblastoma
Rani George, MD, PhD
Associate Professor of Pediatrics, Harvard Medical School
Dept. of Pediatric Hematology/Oncology
Dana-Farber Cancer Institute/Boston Children's Hospital
Original lecture date: October 29
Organized Destruction and Destructive Organization: The Diversity of Immune Responses Towards Tumors and Pathogens
Paul G. Thomas, PhD
Faculty Member, Department of Immunology
St. Jude Children's Research Hospital
Original lecture date: November 5
Targeting Neuron-Glial Interactions in Childhood Brain Cancer
Michelle Monje, MD, PhD
Associate Professor, Neurology & Neurological Sciences
Stanford University
Original lecture date: November 12
Emerging Late Effects of Targeted Molecular Therapies
Eric Chow, MD, MPH
Associate Professor, Clinical Research Division
Associate Professor, Public Health Sciences Division
Director, Prevention Center Shared Resource
Fred Hutchinson Cancer Research Center
Medical Director, Cancer Survivorship Program
Seattle Children's Hospital
Associate Professor, Pediatrics
University of Washington
Original lecture date: November 19
Comprehensive Cancer Center
St. Jude is the first and only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children.
