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ExAMS: Medication Adherence in Children with Sickle Cell Disease

About this study

Hydroxyurea is a medicine used to treat sickle cell disease. St. Jude is looking for new ways to measure how often you take your hydroxyurea as prescribed by your doctor. This study will test a new type of pill bottle to see if it can help you to remember to take your medicine regularly and at the right time. The AdhereTech smart bottle is about the same size as a normal pill bottle and has the same safety cap that opens as a regular bottle does. The bottle is approved by the U.S. Food and Drug Administration (FDA).

In this study, you will store your medication in the smart bottle. The bottle will record when you open the container, and it will send that information to a computer server. The smart bottle can tell when your medicine is low. It can also light up, make sounds and send you text messages to remind you to take your medication.

This study may help you learn more about your disease and how to take your medication. The information we learn from the study may also help other young sickle cell patients take their medication as prescribed.

Eligibility overview

  • Diagnosis of sickle cell disease
  • At least 12 years old and younger than 18 years old
  • On a stable hydroxyurea dose in pill formation for 6 months or longer
  • Lives with legal guardian
  • Able to return to clinic at 4-week intervals

The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.


Full title:

Exploring Adherence Monitoring in Sickle Cell Disease

Study goal:

The main goal of this study is to find out if the smart bottle is good at measuring whether you have taken your medication and if you like using the smart bottle.


Sickle cell disease


At least 12 years old and younger than 18 years old

Clinical trials categories:

Blood Disorders Sickle Cell Disease

For physicians and researchers

Patients accepted to St. Jude must be referred by a physician or other qualified medical professional. Learn how St. Jude can partner with you to care for your patient.


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