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HALGG: Hippocampal-Avoidance Using Proton Therapy in Children with Brain Tumors

About this study

This study examines how a specific proton therapy radiation treatment affects memory and learning in young patients with low-grade glioma brain tumors. Radiation therapy is a standard treatment for low-grade gliomas. Proton therapy is a type of radiation therapy.

In this study, the proton therapy will be designed to avoid the part of the brain called the hippocampus. The hippocampus is important for memory and thinking. Other studies have shown that memory is preserved in adult patients when radiation therapy avoids the hippocampus. There is no proof of this in children, adolescents and young adults.

You may or may not benefit from taking part in this study. However, you may help doctors learn more about your cancer which may help children and adolescents in the future.

Eligibility overview

  • At least 6 years old and younger than 22
  • Diagnosis of low-grade glioma

The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.


Full title:

Phase II Study of Hippocampal-Avoidance Using Proton Therapy in Low-Grade Glioma

Study goal:

The main purpose of this study is to find out what happens, good and bad, to memory and learning when the hippocampus is avoided during proton therapy radiation.


Low-grade glioma


At least 6 years old and younger than 22

For physicians and researchers

Patients accepted to St. Jude must be referred by a physician or other qualified medical professional. Learn how St. Jude can partner with you to care for your patient.


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