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IMPAACT2002: Behavioral Therapy and Medication for Depression among Youth with HIV

About this study

HIV is the term used for human immunodeficiency virus. It is a virus that attacks the body’s immune system and weakens your ability to fight off infection. HIV is spread from one person to another person through contact with blood and some other bodily fluids.

Many adolescents and young adults with HIV struggle with depression. Left untreated, depression can lead to more serious health problems. It can also make it harder to perform everyday tasks and functions.

This study is open to adolescents and young adults with HIV and depression. St. Jude is one of several locations in the United States where the study will be held.

If you participate in this study at St. Jude, you will receive counseling, also known as Cognitive Behavioral Therapy. You may also be given medicine. Researchers will use a special method, known as an algorithm, to review and suggest medicines to treat your depression. 

Eligibility overview

  • 12 to 24 years old
  • Receiving mental health or HIV-related care at participating IMPAACT site
  • HIV-positive
  • Diagnosis of nonpsychotic depression
  • Current depressive symptoms that warrant intervention
  • Reads and speaks English

The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.


Full title:

Combined Cognitive Behavioral Therapy and a Medication Management Algorithm for Treatment of Depression among Youth Living with HIV in the U.S.

Study goal:

The main purpose of this trial is to see how well the combination of a specific type of counseling and medication management treats depression in adolescents and young adults with HIV. Researchers want to find out if this combination therapy treats depression better than standard treatment.


HIV, depression


12 to 24 years old

For physicians and researchers

Patients accepted to St. Jude must be referred by a physician or other qualified medical professional. Learn how St. Jude can partner with you to care for your patient.


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