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LCH-IV: Affects of Tailored Treatments for Langerhans Cell Histiocytosis

About this study

Langerhans cell histiocytosis (LCH) is a rare disease that causes too many Langerhans cells (a type of white blood cell) to grow. It is most common in children and young adults. LCH can affect many different parts of the body, including the bones, skin and lungs. It can damage these tissues and organs and also affect the pituitary gland. This gland makes hormones that control many body functions, such as growth.

Previous clinical trials have improved the treatment and care for children with LCH. However, some patients still do not respond to initial treatment. Others may respond to initial treatment but the disease comes back later. In this study, researchers want to tailor treatment, based on the extent and type of LCH patients have and how they respond to therapy. Participants will be divided into different groups, depending on the level of disease they have. Each group is called a stratum.

Eligibility overview

  • Diagnosis of Langerhans cell histiocytosis
  • Younger than 18 years old
  • Meets inclusion criteria for the respective stratum

The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.


Full title:

International Collaborative Treatment Protocol for Children and Adolescents with Langerhans Cell Histiocytosis

Study goal:

The main goal of this study is to see how tailored treatments affect LCH in children and adolescents.


Younger than 18 years old

Clinical trials categories:

Immune Disorders Langerhans Cell Histiocytosis

For physicians and researchers

Patients accepted to St. Jude must be referred by a physician or other qualified medical professional. Learn how St. Jude can partner with you to care for your patient.


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