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MACMEL: A Study to Analyze Melanoma Lesions in Children and Teens

About this study

Melanoma is the most serious form of skin cancer because it can spread to other parts of the body. The most common cause of melanoma is ultraviolet (UV) radiation from the sun or tanning beds. Although the overall number of children and adolescents with melanoma is relatively small, it is the most common skin cancer in children and is increasing. Teens between the ages of 15 and 19 have the highest rates of childhood melanoma.

There are several types of melanoma tumors, and each one has unique characteristics. Medical tests can help doctors identify these characteristics. Doctors can use that information to decide the best way to treat that specific type of tumor.

Eligibility overview

  • Diagnosed with a melanoma tumor that is malignant (cancerous) or that might be cancerous. Tumors may include:
    • Conventional or “adult-type” melanoma
    • Spitzoid melanoma/atypical Spitz tumor
    • Congenital melanoma
    • Melanoma arising in a giant congenital nevus
    • Melanocytic lesions with indeterminate biological behavior (e.g., pigment-synthesizing melanomas)
  • Up to 18 years of age

The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.


Full title:

Molecular Analysis of Childhood and Adolescent Melanocytic Lesions

Study goal:

Researchers in this study want to learn more about melanoma tumors in children and adolescents. They want to understand the different types of tumors better and learn how each type responds to treatment. They also want to find out why some children and teens are more likely to develop melanoma. Doctors hope this information will help them decide which melanoma treatments are most effective. They also hope to use this information to develop new treatments for children with melanoma.




Up to 18 years old

Clinical trials categories:

Childhood Cancer Solid Tumors Melanoma

For physicians and researchers

Patients accepted to St. Jude must be referred by a physician or other qualified medical professional. Learn how St. Jude can partner with you to care for your patient.


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