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SCDCogO2: Analyzing Oxygen Saturation and Neurocognitive Functioning in Patients with Sickle Cell Disease

About this study

This study uses functional near-infrared spectroscopy (fNIRS) to measure brain oxygen use and brain activity in patients with sickle cell anemia. Scientists want to find out if fNIRS can find differences in:

  • Brain activity
  • How the brain uses oxygen

Scientists will compare the results from patients and their siblings. This will help us understand how well this technology works.

Patients and siblings will take a test that measures thinking skills such as language, attention and memory. During the tests, they will wear a cap with wires that connect to a laptop computer. After the cap is removed, they will do a final set of tasks on the computer.

Parents will answer questions on a form.

Details that scientists learn from this study may help other patients in the future.

Eligibility overview

This clinical trial is open only to patients at the St. Jude Children’s Research Hospital and their siblings.

St. Jude Patients

  • 8 to 17 years old
  • Sickle cell anemia
  • Treated with hydroxyurea
  • Enrolled in the Sickle Cell Clinical Research Intervention Program (SCCRIP) clinical trial
  • Have completed Sickle Cell Assessment of Neuropsychology Skills (SCANS) assessment
  • Read and speak English


  • Siblings of St. Jude patients with sickle cell disease
  • Do not have sickle cell disease
  • 8 to 17 years old

The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.


Full title:

Cerebral Hemodynamics and Neurocognitive Functioning in Sickle Cell Disease

Study goal:

This study aims to find out if fNIRS can find differences in brain oxygen use and brain activity in patients with sickle cell disease. We will compare results from these patients with results from their siblings.


8 to 17 years old

For physicians and researchers

Patients accepted to St. Jude must be referred by a physician or other qualified medical professional. Learn how St. Jude can partner with you to care for your patient.


Learn more