About this study
SJRET6 is a Phase II clinical trial for children with newly diagnosed retinoblastoma that has not spread beyond the eye. Retinoblastoma is a rare cancer of the retina, which is the thin membrane on the inside back of the eye that is stimulated by light. This type of cancer is usually diagnosed before a child is 3 years old and can be passed down in families (inherited from parents).
The most important goal of retinoblastoma treatment at St. Jude Children’s Research Hospital is always to cure your child’s cancer and save your child’s life. Treatments are also focused on increasing the chances of saving your child’s eye and vision as much as possible, while still trying to completely destroy the cancer.
Treatment
There are three parts to this study:
- Staging– the first step is to find out how much tumor is in the eye and where it has spread.
- Treatment – treatment can include surgery, chemotherapy, laser therapy or freezing/heat treatments directly to the eye and radiation therapy. The treatment is tailored specifically for your child depending on:
- whether the tumor affects one eye or both eyes
- how far the tumor has spread to areas in and around the eye, or outside the eye
- Follow-up – there will be regular follow-up visits for five years after treatment is completed.
Eligibility overview
- Newly diagnosed retinoblastoma that has not spread beyond the eye
- Has not received previous treatment with chemotherapy or radiation therapy
- Patients who have been diagnosed with retinoblastoma in one eye who did not receive chemotherapy, but then developed retinoblastoma in the opposite eye