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Equipo de tratamiento de la predisposición al cáncer
El Programa de predisposición al cáncer de St. Jude Children’s Research Hospital ayuda a evaluar y atender a niños que tienen un mayor riesgo genético de tener cáncer. Somos un equipo de médicos, personal de enfermería y consejeros genéticos que trabajan junto con las familias para averiguar si el cáncer de un niño puede ser hereditario (pasado de generación en generación). Trabajamos en estrecha colaboración con otros médicos e investigadores de St. Jude para encontrar nuevas y mejores formas de ayudar a las familias que tienen una probabilidad más alta de lo normal de presentar cáncer.
Cuerpo docente
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Kim E. Nichols, MD
Member, St. Jude Faculty
Director, Cancer Predisposition Division
Kim E. Nichols, MD
Member, St. Jude Faculty
Director, Cancer Predisposition Division
Afiliaciones
Intereses de investigación
- Identifying novel genetic causes of childhood cancer
- Optimizing methods of tumor surveillance for children with increased cancer risk
- Evaluating the factors that influence parent and adolescent decision making and communication around genetic testing for heritable cancer risk
- Understanding the behavioral and psychological impacts of cancer genetic testing on children and their families
- Increasing understanding and developing new therapies for malignant and non-malignant hematologic disorders, including B-cell leukemias and lymphomas, hemophagocytic lymphohistiocytosis and Epstein-Barr virus-associated lymphoproliferations
Información de contacto
Kim E. Nichols, MD
Cancer Predisposition
MS 1170, Room I3311
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Melissa Perrino, MD
Assistant Member, St. Jude Faculty
Afiliaciones
Intereses de investigación
- Identification of germline variants and their role in driving tumor formation
- Refining surveillance guidelines for patients with underlying germline predisposition
- Targetability of tumor and germline variants in cancer therapy and prevention
- Effects of tumor and germline genomic variants on treatment outcome
Información de contacto
Melissa Perrino, MD
Cancer Predisposition
MS 1170, Room I3312
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Personal
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Sabrin Albeituni, PhD
Sr. Scientist
Afiliaciones
Intereses de investigación
I am a Sr. Scientist with a strong interest in understanding the regulation of T cell responses by myeloid cells during normal immune homeostasis and in conditions of hyperinflammation. My research focuses on investigating the cellular and molecular mechanisms driving the pathogenesis of hemophagocytic lymphohistiocytosis (HLH)- a severe hyperinflammatory syndrome characterized by excessive immune cell activation and multi-system organ failure. In the Nichols’ laboratory, our goal is to advance innovative therapeutic strategies to mitigate hyperinflammation and improve clinical outcomes in patients with HLH.
Información de contacto
Sabrin Albeituni, PhD
Cancer Predisposition
MS 343, Room D4022
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Melinda S. Artz
Program Coordinator
Afiliaciones
Información de contacto
Melinda S. Artz
Department of Oncology Division of Cancer Predisposition
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Aidin Foroutan
Bioinformatics Research Scientist
Afiliaciones
Intereses de investigación
I am a Bioinformatics Research Scientist with research interest in developing bioinformatics pipelines for the analysis of large “omics” datasets to uncover cell type-specific molecular mechanisms of childhood and adult cancers.
Towards this end, my research focuses on:
- Developing bioinformatics workflows for genomic variant discovery, interpretation, and prioritization related to germline cancer predisposition genes.
- Integrative analysis of multiple omics data to uncover mechanisms of cell type-specific gene dysregulation in cancers.
Información de contacto
Aidin Foroutan
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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LilyAnne Grieve
Certified Genetic Counselor I
Afiliaciones
Intereses de investigación
I am a pediatric cancer genetic counselor whose research interests include:
- Utilizing genetic, family history, and personal history information to guide care of patients with cancer predisposition syndromes.
- Exploring patient coping and understanding related cancer predisposition diagnoses and how these factors evolve in different stages of life.
- Addressing access and barriers to clinical genetics healthcare in underserved communities.
Información de contacto
LilyAnne Grieve
Cancer Predisposition Program
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Lynn Harrison, MPA, CCRP
Manager - Clinical Operations
Afiliaciones
Información de contacto
Lynn Harrison, MPA, CCRP
Cancer Predisposition
MS 1170, Room I3318
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Stacy Hines-Dowell, DNP, FNP-BC, AGN-BC, ACGN
Lead of Clinical Operations - Division of Cancer Predisposition | Doctor of Nursing Practice | Advanced Practice Provider III
Stacy Hines-Dowell, DNP, FNP-BC, AGN-BC, ACGN
Lead of Clinical Operations - Division of Cancer Predisposition | Doctor of Nursing Practice | Advanced Practice Provider III
Afiliaciones
Intereses de investigación
My core mission of clinical and translational research is to develop novel approaches for delivery of genetic health education directly to underserved communities. The demarcation of translational research into T1 (bench-to-bedside) and T2 (bedside-to-community) activities corresponds to two significant bottlenecks in clinical research. I'm interested in newborn screening, sickle cell disease and education pertaining to genetics and genomics literacy.
Información de contacto
Stacy Hines-Dowell, DNP, FNP-BC, AGN-BC, ACGN
Cancer Predisposition
MS 1170, Room I3331
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Laura Howell, MLS (ASCPCM), CCRP
Clinical Research Associate II
Afiliaciones
Intereses de investigación
I joined St. Jude in June of 2005 as a Medical Laboratory Scientist in the Molecular Microbiology Lab with the Department of Pathology. I transitioned to Pharmaceutical Sciences in 2011 where I performed therapeutic drug monitoring tests in the PK Clinical Lab. During my time in Pharm Sciences, I got to experience the Total 16 and Total 17 research protocols, which sparked my interest in clinical research. This led me to pursue my role as a Clinical Research Associate in the Division of Cancer Predisposition.
Información de contacto
Laura Howell, MLS (ASCPCM), CCRP
Oncology Department
262 Danny Thomas Place
Memphis, TN 38105-3678
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Manish R. Kubal, MBA (MIS), MHA, MSIS
Database Analyst II
Afiliaciones
Intereses de investigación
I have worked in different industries and handled data management and analysis requirements. I develop, maintain and update the Cancer Predisposition Division’s clinical and non-clinical databases needed to coordinate protocol research information management while ensuring the consistency of standards, procedures and content. I am assigned to manage all of the division’s data management requirements including integration of information from various disparate systems; data modeling; data analysis; and dissemination of data to various entities that interact with the division.
Información de contacto
Manish R. Kubal, MBA (MIS), MHA, MSIS
Cancer Predisposition
MS 260, Room B1109
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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JaQuel Maise
Graduate Student
Afiliaciones
Información de contacto
JaQuel Maise
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105
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Rose McGee, MS, CGC
Certified Genetic Counselor III
Afiliaciones
Intereses de investigación
I am a pediatric cancer genetic counselor with interests in:
- Identification, surveillance and genotype-phenotype correlations of cancer predisposition syndromes. Syndromes of particular interest are constitutional mismatch repair deficiency (CMMRD) syndrome and DICER1 syndrome
- Incorporation of clinical genomics into pediatric cancer care
- Communication of complex information to children of varying ages, assessing impact of illness on the family and pre-symptomatic testing of minors for cancer predisposition
Información de contacto
Rose McGee, MS, CGC
Cancer Predisposition
MS 1170, Room I3314
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Alise Blake
Senior Genetic Counselor
Afiliaciones
Intereses de investigación
I am a pediatric cancer genetic counselor with a passion for helping patients and their families navigate complex genetic information and the implications of cancer predisposition syndromes.
Specific research interests include:
- Utilizing genetic information to guide screening and treatment of individuals with cancer predisposition syndromes.
- Exploring Family dynamics, belief systems, and cultural differences as they relate to cancer predisposition syndromes and psychosocial coping strategies
- Identifying gaps in genetics education and building resources to meet the identified needs
Información de contacto
Alise Blake
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Ninad Oak, PhD
Lead Bioinformatics Research Scientist
Afiliaciones
Intereses de investigación
- Genetic Basis of Pediatric Cancer Predisposition: Investigating inherited and somatic genetic variations underlying pediatric cancer predisposition syndromes by leveraging large-scale genomic datasets, including analysis of >6,000 pediatric cancer genomes from St. Jude.
- Functional Genomics in Mouse Models: Utilizing mouse models to perform functional genomics analyses, with a focus on understanding gene regulation and mechanisms of hematopoiesis, as well as their implications for cancer predisposition.
Información de contacto
Ninad Oak, PhD
Cancer Presdisposition/Oncology
MS 1135, Room IA6218.5
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Lena Oslund
Administrative Specialist
Afiliaciones
Información de contacto
Lena Oslund
Oncology
St. Jude Childen's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Arti Pandey, PhD, CGC
Certified Genetic Counselor l
Afiliaciones
Intereses de investigación
- Cancer predisposition in pediatric hematological malignancies
Información de contacto
Arti Pandey, PhD, CGC
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Leslie Taylor
Program Coordinator, Cancer Predisposition
Afiliaciones
Intereses de investigación
As we continue to better understand hereditary childhood cancer, I am interested in the process of communication, coordination and knowledge-sharing with patients and families. I know that being a part of the Cancer Predisposition Program at St. Jude, I am able to aid in education as well as early detection of hereditary cancer. As a nurse, you always want to know that you make a difference in someone’s life. That is why I love working at St. Jude Children's Research Hospital.
Información de contacto
Leslie Taylor
Cancer Predisposition
MS 1170, Room I3016.04
Danny Thomas Place
Memphis, TN 38105-3678
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Roshina Thapa, PhD
Postdoctoral Research Associate
Afiliaciones
Información de contacto
Roshina Thapa, PhD
Department of Oncology
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105
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Tina Thornton
Sr. Administrative Specialist
Afiliaciones
Información de contacto
Tina Thornton
Cancer Predisposition/Oncology
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Paige Turner
Clinical Research Associate-RN II
Afiliaciones
Información de contacto
Paige Turner
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
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Rolanda Woods, MBA
Lead Researcher
Afiliaciones
Información de contacto
Rolanda Woods, MBA
Cancer Predisposition
MS 343, Room D4022
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
