Healthy Volunteers Clinical Trials

 

St. Jude Clinical Trials

BUZZOFF: Antimalarial Drug Effectiveness in Healthy Adults

First-in-Human, Dose-Escalation Study of an Oral Plasmodium Falciparum Plasma Membrane Protein Inhibitor

Diseases Treated:

Malaria

Eligibility:

  • Healthy male or female adults
  • Age 18 to 55 years old
  • Minimum weight of 50 kg with BMI between 18 and 34 kg/m^2
  • Females must be post-menopausal or have documented hysterectomy or bilateral oophorectomy
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FLUVIT: A Double-Blind Randomized, Placebo Controlled Study of Antibody Induction By Vitamin Supplementation At The Time Of Influenza Virus Vaccination In Children

Eligibility:

  • Participant is age two (2) to eight (8) years inclusive at the time of enrollment.
  • Participant is not currently using investigational or immunosuppressive drugs (e.g. steroids) at the time of enrollment.
  • Participant is not currently taking a daily (routine) Vitamin A, D or multi-vitamin. Note: Participant who report occasional or sporadic vitamin use will be allowed to enroll.
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SENDAI: A Phase I Study of Unmodified Live Intranasal Sendai Virus Vaccine in Children and Toddlers: Assessment of Safety and Immunogenicity

Eligibility:

  • Child is greater than or equal to twelve (12) months and less than twenty-four (24) months.
  • Child has adequate blood, liver and kidney function.
  • Child has no history of lung disease, asthma, and hospitalization for respiratory illness, immunodeficiency, sickle cell disease, or any other serious underlying condition.
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XPD12-077: Cognitive, Academic and Psychosocial Functioning in Long-Term Survivors of Pediatric Stem Cell Transplantation

Eligibility:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.

St. Jude patients:

  • Treated with an allogeneic bone marrow or stem cell transplant at St. Jude
  • 8 years of age or older
  • Younger than 21 at time of transplant
  • More than 5 years from date of transplant

Healthy volunteers (comparison group):

  • 8 years of age or older
  • Primarily speaks English
  • No known history of serious illness
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