Histiocytosis Clinical Trials

 

Collaborative Clinical Trials

HSESID: Database for HLH Immunodeficiency Disease

A Registry for Hemophagocytic Lymphohistiocytosis (HLH)

Eligibility:

  • Diagnosis of a primary immunodeficiency predisposed to hemophagocytic lymphohistiocytosis
  • Meets at least 4 of 8 diagnostic criteria for HLH as defined by the Histiocyte Society and is receiving HLH-directed therapy
  • High suspicion of isolated Central Nervous System-HLH and is receiving HLH-directed therapy
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LCH-CLO: Clofarabine for Langerhans Cell Histiocytosis and LCH-related disorders

Phase II Study of Clofarabine in Patients with Recurrent or Refractory Langerhans Cell Histiocytosis and LCH-Related Disorders

Diseases Treated:

Langerhans cell histiocytosis and LCH-related disorders

Eligibility:

  • Prior diagnosis of Langerhans cell histiocytosis or LCH-related disorder
  • Evidence of active disease
  • Performance Score > 70% (use Lansky score for age < 16 and Karnofsky score for age ≥16)
  • Any age
  • Adequate organ functions
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LCH-IV: Clinical Trial for Children and Adolescents with Langerhans Cell Histiocytosis

International Collaborative Treatment Protocol for Children and Adolescents with Langerhans Cell Histiocytosis

Diseases Treated:

Langerhans cell histiocytosis

Eligibility:

  • Diagnosis of Langerhans cell histiocytosis
  • Younger than 18 years old
  • Meets inclusion criteria for the respective stratum

 

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