Sickle Cell Disease Clinical Trials

 

St. Jude Clinical Trials

EPSTRV: Retroviral Vector Mediated Globin Gene Transfer to Correct Sickle Cell Anemia or Thalassemia

Diseases Treated:

Sickle cell anemia

Eligibility:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.

  • Participant’s age is equal to or greater than two (2) years old
  • No active sickle cell disease
  • Adequate blood counts
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INSIGHT-HD: Investigating the Genetics of Hematologic Diseases

Diseases Treated:

Non-malignant blood diseases (non-therapeutic)

Eligibility:

  • Receiving therapy or a consultation for a non-malignant blood disorder
  • Biological relatives (with or without a non-malignant blood disorder) who agree to undergo genetic testing
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MEMREAD: Working Memory and School Readiness in Preschool-aged Children with Sickle Cell Disease: Family and Environmental Factors

Diseases Treated:

Sickle cell disease

Eligibility:

This is a non-therapeutic clinical trial open to St. Jude patients only.

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PMVOC: Pain Management of Vaso-Occlusive Crisis in Children and Young Adults with Sickle Cell Disease

Diseases Treated:

Sickle cell disease

Eligibility:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.

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PMVOCVR: Virtual Reality Therapy for Vaso-Occlusive Crisis in Patients with Sickle Cell Disease

Diseases Treated:

Sickle cell disease

Eligibility:

This is a non-therapeutic clinical trial that is open only to patients at St. Jude or Methodist Healthcare.

  • Between 6 and 25 years old
  • Diagnosed with sickle cell disease
  • Seeking care for acute vaso-occlusive crisis pain at St. Jude Children’s Research Hospital or Methodist Healthcare
  • Speaks English
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REHASH: Barriers to Hydroxyurea Adherence for Sickle Cell Disease

Diseases Treated:

Sickle cell disease

Eligibility:

This study is limited to patients living in the Memphis, Tennessee region.

Phase I

Phase II

  • Diagnosis of sickle cell disease
  • Between 15 and 44.9 years old
  • Receiving hydroxyurea treatment for sickle cell disease
  • Owns a smart phone
  • Not currently receiving text messages for improving hydroxyurea adherence
  • Not currently undergoing hydroxyurea dose escalation
  • Not on any investigational new drug intervention study for sickle cell disease
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SCCRIP: Sickle Cell Research and Intervention Program

Diseases Treated:

Sickle cell disease

Eligibility:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.
  • Participant has a diagnosis of Sickle Cell Disease of any genotype.
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Collaborative Clinical Trials

NOTCHES1: Novel Therapies in Children with Sickle Cell Disease

Diseases Treated:

Sickle cell disease

Eligibility:

  • 12 to 17 years old
  • Diagnosis of sickle cell disease
  • Able to swallow capsules

 

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TADO: A Study of Prasugrel in Pediatric Participants With Sickle Cell Disease (SCD)

Diseases Treated:

Sickle cell disease

Eligibility:

  • Participant with Sickle Cell Disease (laboratory determined HbSS or HbS beta zero thalassemia) who have had >2 episodes of Vaso-occlusive crisis in the past year. 
  • Participants >2 years of age and < 18 years of age.
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