Supportive Infectious Diseases Studies

Non-therapeutic protocols address such issues as side effects or long-term effects of therapy, quality of life, making testing easier on the children, prevention of pain, and issues related to nutrition and stress. There are also tissue and blood banking protocols for laboratory researchers who are studying diseases and searching for underlying causes and cures. The research at St. Jude is designed to include all aspects related to the care of sick children and their families.

St. Jude Clinical Trials

BUZZOFF: Antimalarial Drug Effectiveness in Healthy Adults

Diseases Treated:

Malaria

Eligibility:

  • Healthy male or female adults
  • Age 18 to 55 years old
  • Minimum weight of 50 kg with BMI between 18 and 34 kg/m^2
  • Females must be post-menopausal or have documented hysterectomy or bilateral oophorectomy
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CaRMA: Catheter Resistance Monitoring to Predict Catheter-Associated Adverse Events in Children and Adolescents: A Feasibility Study

Eligibility:

  • This is a non-therapeutic clinical trial that is only open to St. Jude patients.
  • Participant is receiving treatment for any disease at St. Jude.
  • Participant is age ≥ 5 years to < 25 years.
  • Participant has single or double lumen tunneled CVAD (ports not eligible).
  • Participant’s treating clinician does not plan to remove CVAD within 12 weeks.
  • Participant has not been previously enrolled in the CaRMA study or had past catheter resistance monitoring.
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INMED: Investigation of Incentives to Promote Medication Adherence Among HIV-Infected Adolescents on Antiretroviral Therapy.

Eligibility:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.
  • Participant is > 16 and < 24 years of age.
  • Participant is diagnosed with HIV.
  • Participant is aware of his/her HIV diagnosis.
  • Participant understands either written or spoken English.
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Collaborative Clinical Trials

AT1026: Pharmacokinetic Study of Antiretroviral Drugs and Related Drugs During and After Pregnancy

Diseases Treated:

HIV Infection

Eligibility:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.

  • The subject has been enrolled on IMPAACT P1025.
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ATN129: Comparing the Effectiveness of Two Alcohol+Adherence Interventions for HIV+ Youth

Diseases Treated:

HIV

Eligibility:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.

  • Participant receives services at St. Jude.
  • Participant has HIV-1 Infection.
  • Participant is between the ages of 16 years and 24 years.
  • Participant has been offered a prescription for antiretroviral (ARV) medications.
  • Participant is able to understand, read, and speak English.
  • Participant has used alcohol in the last 12 weeks prior to screening.
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CCL1034: Chlorhexidine Gluconate Cleansing in Preventing Central Line Associated Bloodstream Infection and Acquisition of Multi-drug Resistant Organisms in Younger Patients With Cancer or Undergoing Donor Stem Cell Transplant

Diseases Treated:

Cancer or allogeneic hematopoietic cell transplantation

Eligibility:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.

  • Participant > 2 months of age and < 21 years of age at enrollment.
  • Participant has or is scheduled to have an external tunneled central venous catheter (CVC) (Broviacs, Hickmans, tunneled percutaneously inserted central PICCs), that is expected to remain in place for an additional > 3 months.
  • Participant with a current or previous line infection completed antibiotics > 14 days ago.
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