Supportive Leukemias / Lymphomas Studies

Non-therapeutic protocols address such issues as side effects or long-term effects of therapy, quality of life, making testing easier on the children, prevention of pain, and issues related to nutrition and stress. There are also tissue and blood banking protocols for laboratory researchers who are studying diseases and searching for underlying causes and cures. The research at St. Jude is designed to include all aspects related to the care of sick children and their families.

St. Jude Clinical Trials

APNEA: Sleep Apnea in Hodgkin Lymphoma Survivors Treated with Radiation to the Chest

Diseases Treated:

Hodgkin lymphoma


This is a non-therapeutic clinical trial that is only open to former St. Jude patients, their family members and friends.

Hodgkin lymphoma survivor

  • Current St. Jude LIFE participant, treated with thoracic radiation for Hodgkin lymphoma
  • At least 18 years old
  • At least 5 years from original diagnosis

Comparison group

  • Sibling, parent, relative or friend of a current or former St. Jude patient
  • At least 18 years old
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DSCOG: Learning, Behavior and Social Skills in Survivors of Childhood Leukemia with Down syndrome

Diseases Treated:



This is a non-therapeutic clinical trial that is open only to patients who were treated at St. Jude Children’s Research Hospital since 1980 and are currently followed at the hospital.

  • St. Jude Children’s Research Hospital patient with acute leukemia (i.e., ALL or AML)
  • Trisomy 21 Down syndrome diagnosis
  • Completed all cancer therapy at St. Jude since 1980 and at least six months prior to study visit
  • English as the primary language
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LiSTENING: Learning in Story: Elicited Narrative Informs Navigating Genetics


This is a non-therapeutic clinical trial open to St. Jude patients only.

Participants have been pre-identified by the primary care team as an English-speaking, four-member family unit diagnosed with TP53 mutation.

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Collaborative Clinical Trials

ALTE1631: Web-based Exercise Study for Children and Adolescents with Acute Lymphoblastic Leukemia

Diseases Treated:

Acute lymphoblastic leukemia


This is a non-therapeutic clinical trial open to patients receiving treatment at a Children’s Oncology Group (COG)-affiliated institution.

  • At least 8 years old and younger than 16 years old
  • Newly diagnosed acute lymphoblastic leukemia (ALL), in first remission
  • Completed chemotherapy within past 90 days
  • Performance status corresponding to ECOG scores of 0, 1, 2
  • Fewer than 420 minutes of moderate to vigorous physical activity (MVPA) over the last week
  • Access to smart phone (Android 4.3 or later, iOS 7.1 or later or computer with connection to the internet)
  • Able to write and read English (patient and at least one parent/guardian)
  • Not pregnant
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NCBP01: Safety Study of Unlicensed, Investigational Cord Blood Units Manufactured by the NCBP for Unrelated Transplantation

Diseases Treated:

Leukemia and other blood diseases


This is a non-therapeutic clinical trial that is only open to St. Jude patients.

  • Participant is receiving an allogeneic hematopoietic stem cell (HSC) transplant at St. Jude Children's Research Hospital using an unlicensed cord blood unit (CBU).
  • Participant may be of any age and either gender.
  • Participant has a medical disorder affecting the hematopoietic system that is inherited, acquired, or a result from myeloablative treatment.
  • Participant is receiving HPC-CORD BLOOD product manufactured by NCBP (at least one, if the graft contains more than one units).
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