Supportive Sickle Cell Disease Studies

Non-therapeutic protocols address such issues as side effects or long-term effects of therapy, quality of life, making testing easier on the children, prevention of pain, and issues related to nutrition and stress. There are also tissue and blood banking protocols for laboratory researchers who are studying diseases and searching for underlying causes and cures. The research at St. Jude is designed to include all aspects related to the care of sick children and their families.

St. Jude Clinical Trials

EPSTRV: Retroviral Vector Mediated Globin Gene Transfer to Correct Sickle Cell Anemia or Thalassemia

Diseases Treated:

Sickle cell anemia

Eligibility:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.

  • Participant’s age is equal to or greater than two (2) years old
  • No active sickle cell disease
  • Adequate blood counts
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INSIGHT-HD: Investigating the Genetics of Hematologic Diseases

Diseases Treated:

Non-malignant blood diseases (non-therapeutic)

Eligibility:

  • Receiving therapy or a consultation for a non-malignant blood disorder
  • Biological relatives (with or without a non-malignant blood disorder) who agree to undergo genetic testing
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MEMREAD: Working Memory and School Readiness in Preschool-aged Children with Sickle Cell Disease: Family and Environmental Factors

Diseases Treated:

Sickle cell disease

Eligibility:

This is a non-therapeutic clinical trial open to St. Jude patients only.

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MIDAS: Massive Iron Overload Assessment

Diseases Treated:

Iron overload 

Eligibility:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.

  • Participant has a history of 12 or more lifetime erythrocyte transfusions.
  • Participant has a need for liver iron content assessment.
  • No contra-indication to having an MRI exam, such as the presence of metal in the body.
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PMVOC: Pain Management of Vaso-Occlusive Crisis in Children and Young Adults with Sickle Cell Disease

Diseases Treated:

Sickle cell disease

Eligibility:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.

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SCCRIP: Sickle Cell Research and Intervention Program

Diseases Treated:

Sickle cell disease

Eligibility:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.
  • Participant has a diagnosis of Sickle Cell Disease of any genotype.
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