TRIALS: Transfusional Iron Overload Among Leukemia Survivors

Category:

Leukemia / Lymphoma

Eligibility Overview:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.

Description

Red cell transfusions are an important part of supportive cancer therapy. The iron in the transfused blood may build up in the body since the body has no way to get rid of extra iron. Iron tends to build up in the liver and the heart muscle. It is unknown if iron build-up is present many years after completing cancer therapy. It is also not known if extra iron causes harm to internal organs. Doctors want to understand if iron build-up (called “iron overload”) exists in survivors of leukemia. They also want to know if iron overload can cause injury to organs if it is present.

Objectives

  • To find out how many long-term survivors of leukemia have iron overload by using MRI testing.
  • To study how the number of red blood cell transfusions you received determines whether you have iron overload.
  • To explore how your age at the time of cancer therapy, the length of time from therapy, and gender affects whether you develop iron overload.
  • To find out if iron overload is causing problems with your organs.

Eligibility criteria, among others, include

Inclusion Criteria

  • Participant had a diagnosis of hematologic malignancy (ALL or AML) that was treated at St. Jude Children’s Research Hospital with conventional chemotherapy.
  • At time of enrollment participant should be > 5 and < 10 years from diagnosis of primary cancer.
  • Participant is not undergoing active therapy for relapse or subsequent malignant neoplasm.
  • Recipient of > 50 ml/kg packed red blood cell transfusions during therapy

Exclusion Criteria

  • Participant is pregnant.
  • If participant is an adult, requires IV sedation to undergo MRI.

Principal Investigator

Jane Hankins, MD, MS

St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105  USA
Voice: 1-888-226-4343 or 901-595-4055
24-Hour Emergency Access Pager: 1-800-349-4334
Email: referralinfo@stjude.org

The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.