Bone Marrow Transplant Clinical Trials

Diseases Treated:

Acute Myelogenous Leukemia

Eligibility:

• 21 years old or younger
• Relapsed/refractory CD123+ AML, B-ALL, T-ALL or blastic plasmacytoid dendritic cell neoplasm
• Has a suitable bone marrow transplant donor for allogeneic bone marrow transplant

Diseases Treated:

• Acute lymphoblastic leukemia
• Acute myeloid leukemia
• Myelodysplasia
• Hodgkin lymphoma
• Non-Hodgkin lymphoma
• Juvenile myelomonocytic leukemia

Eligibility:

For transplant recipient:

• 21 years or younger
• Does not have a suitable sibling donor or volunteer unrelated donor
• Has a suitable single haplotype matched family member donor
• Diagnosed with high risk hematologic malignancy
• No prior allogeneic hematopoietic cell transplant

Diseases Treated:

X-linked Severe Combined Immunodeficiency (SCID-X1)

Eligibility:

• Diagnosis of Severe Combined Immunodeficiency, X-linked (SCID-X1)
• Newborn to 2 years of age
• No prior therapy with allogeneic stem cell transplantation
• No HIV infection

Diseases Treated:

Acute lymphoblastic leukemia

Eligibility:

Donor eligibility includes:

• At least 18 years old
• At least single haplotype matched family member
• HIV negative
• Not pregnant or breastfeeding

Recipient eligibility includes:

• 21 years old or younger*
• Diagnosed with relapsed and/or refractory CD19-positive leukemia
• Cohort A only – Relapsed and/or refractory CD19-positive leukemia AND previously received a hematopoietic cell transplant from the selected CAR-T donor
• Cohort B only: Can not receive autologous CD19-CAR T-cell therapy (per study)
• Detectable medullary leukemia

* Initial 3 participants must be at least 16 years old.

Diseases Treated:

• Leukemia
• Lymphoma
• Myeloid sarcoma
• Myelodysplastic syndrome

Eligibility:

• 21 years old and younger
• Diagnosed with one of the following that has come back or did not improve after bone marrow transplant
  • Acute lymphoblastic leukemia (ALL)
  • Acute myeloid leukemia
  • Myeloid sarcoma
  • Chronic myeloid leukemia (CML)
  • Juvenile myelomonocytic leukemia (JMML)
  • Myelodysplastic syndrome (MDS)
  • Non-Hodgkin lymphoma (NHL)
• Has a family member who is a suitable stem cell donor

Diseases Treated:

Sickle Cell Disease

Eligibility:

• 25 years old or younger
• Diagnosed with severe sickle cell disease
• Has a suitable HLA-matched sibling donor or single haplotype matched (half matched) family member donor (parents or siblings)

Diseases Treated:

Acute lymphoblastic leukemia

Eligibility:

• Children and young adults up to 21 years old
• Refractory or relapsed CD19+ acute lymphoblastic leukemia (ALL)