St. Jude Clinical Trials
CATCHAML: CAR T-Cell Therapy for Acute Myelogenous Leukemia (AML)
Diseases Treated:
Acute Myelogenous Leukemia
Eligibility:
- 21 years old or younger
- Relapsed/refractory CD123+ AML, B-ALL, T-ALL or blastic plasmacytoid dendritic cell neoplasm
- Has a suitable bone marrow transplant donor for allogeneic bone marrow transplant
HAP2HCT: Partially Matched Family Donor Bone Marrow Transplant in Children and Young Adults with High Risk Cancer
Diseases Treated:
- Acute lymphoblastic leukemia
- Acute myeloid leukemia
- Myelodysplasia
- Hodgkin lymphoma
- Non-Hodgkin lymphoma
- Juvenile myelomonocytic leukemia
Eligibility:
For transplant recipient:
- 21 years or younger
- Does not have a suitable sibling donor or volunteer unrelated donor
- Has a suitable single haplotype matched family member donor
- Diagnosed with high risk hematologic malignancy
- No prior allogeneic hematopoietic cell transplant
LVXSCID-ND: Gene Therapy for X-Linked Severe Combined Immunodeficiency (SCID-X1) in Newly Diagnosed Infants
Diseases Treated:
X-linked Severe Combined Immunodeficiency (SCID-X1)
Eligibility:
- Diagnosis of Severe Combined Immunodeficiency, X-linked (SCID-X1)
- Newborn to 2 years of age
- No prior therapy with allogeneic stem cell transplantation
- No HIV infection
MEMCAR19: Allogeneic CAR T-Cell Therapy for Relapsed/Refractory CD19-Positive Leukemia
Diseases Treated:
Eligibility:
Donor eligibility includes:
- At least 18 years old
- At least single haplotype matched family member
- HIV negative
- Not pregnant or breastfeeding
Recipient eligibility includes:
- 21 years old or younger*
- Diagnosed with relapsed and/or refractory CD19-positive leukemia
- Cohort A only – Relapsed and/or refractory CD19-positive leukemia AND previously received a hematopoietic cell transplant from the selected CAR-T donor
- Cohort B only: Can not receive autologous CD19-CAR T-cell therapy (per study)
- Detectable medullary leukemia
* Initial 3 participants must be at least 16 years old.
REF2HCT: Haploidentical Bone Marrow Transplant for Leukemia and Lymphoma
Diseases Treated:
Eligibility:
- 21 years old and younger
- Diagnosed with one of the following that has come back or did not improve after bone marrow transplant
- Acute lymphoblastic leukemia (ALL)
- Acute myeloid leukemia
- Myeloid sarcoma
- Chronic myeloid leukemia (CML)
- Juvenile myelomonocytic leukemia (JMML)
- Myelodysplastic syndrome (MDS)
- Non-Hodgkin lymphoma (NHL)
- Has a family member who is a suitable stem cell donor
SCDHCT: Reduced Intensity Related Donor HCT for Patients with Severe Sickle Cell Disease
Diseases Treated:
Eligibility:
- 25 years old or younger
- Diagnosed with severe sickle cell disease
- Has a suitable HLA-matched sibling donor or single haplotype matched (half matched) family member donor (parents or siblings)
SJCAR19: CAR T-Cell Therapy for Children and Young Adults with Acute Lymphoblastic Leukemia
Diseases Treated:
Eligibility:
- Children and young adults up to 21 years old
- Refractory or relapsed CD19+ acute lymphoblastic leukemia (ALL)
Collaborative Clinic Trials
None at this time.