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Psychology Clinical Trials

The Psychology Department conducts supportive care clinical trials for patients with cancer and blood disorders. These studies investigate long term effects of therapy, quality of life, and ways to improve health behaviors and psychological functioning.

St. Jude Clinical Trials

CONNECT: Social Experiences of Adolescents and Young Adults with Cancer

Diseases Treated:

Non-therapeutic

Eligibility:

This is a non-therapeutic research study open only to St. Jude patients and their caregivers.

  • 15 to 22 years old 
  • Primary oncology diagnosis 
  • Read and speak English 
View Trial

ExAMS: Medication Adherence in Children with Sickle Cell Disease

Diseases Treated:

Non-therapeutic

Eligibility:

This clinical trial is open only to patients at the St. Jude Children’s Research Hospital Hematology Clinic.

  • Diagnosis of sickle cell disease (SCD)
  • At least 12 years old and younger than 18 years old
  • On a stable hydroxyurea dose in pill formation for 6 months or longer
  • Lives with legal guardian
  • Able to return to clinic at 4-week intervals
View Trial

HBTOP: Healthy Lifestyle Behaviors of Childhood Cancer Survivors

Diseases Treated:

Non-therapeutic

Eligibility:

This is a non-therapeutic research study open only to St. Jude patients and their caregivers.

  • 5 to 17 years old 
  • Diagnosed with malignancy or CNS neoplasm
  • Identified by the St. Jude Transition Oncology Program as a patient transitioning off active cancer therapy
View Trial

LEAPS: Understanding Sickle Cell Disease Transition to Adult Care

Diseases Treated:

Sickle Cell Disease

Eligibility:

This is a non-therapeutic study for patients at St. Jude Children’s Research Hospital and Methodist Adult Comprehensive Sickle Cell Center.

  • Diagnosis of sickle cell disease (SCD)
  • 16 to 20 years old
  • English is primary language
View Trial

MEMCRT: Memantine to Prevent Thinking Problems in Children Receiving Radiation for Certain Brain Tumors

Diseases Treated:

Brain Tumors

Eligibility:

  • Between 6 and 21 years old
  • Diagnosis of localized low-grade gliomacraniopharyngioma, ependymoma, meningioma or germ cell tumor 
  • Initiating focal cranial radiation therapy (photon or proton)
  • Able to swallow pills
  • Participant and parent/legal guardian speak, read and understand English
  • Normal ECG and laboratory tests
  • Adequate vision and hearing
View Trial

RT3CR: Proton Therapy for Pediatric Craniopharyngioma

Diseases Treated:

Craniopharyngioma

Eligibility:

  • 21 years old or younger
  • Diagnosis of craniopharyngioma
View Trial

SCDCogO2: Analyzing Oxygen Saturation and Neurocognitive Functioning in Patients with Sickle Cell Disease

Diseases Treated:

Non-therapeutic

Eligibility:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.

St. Jude Patients

  • 8 to 17 years old 
  • Sickle cell anemia 
  • Enrolled on the Sickle Cell Clinical Research Intervention Program (SCCRIP) clinical trial 
  • Completed Sickle Cell Assessment of Neuropsychology Skills (SCANS) assessment 
  • Being treated with hydroxyurea (maximum tolerated dose) 
  • Read and speak English

Siblings

  • Siblings of St. Jude patients with sickle cell disease 
  • Do not have sickle cell disease 
  • 8 to 17 years old 
View Trial

SCDHCT: Reduced Intensity Related Donor HCT for Patients with Severe Sickle Cell Disease

Diseases Treated:

Sickle Cell Disease

Eligibility:

  • 25 years old or younger
  • Diagnosed with severe sickle cell disease
  • Has a suitable HLA-matched sibling donor or single haplotype matched (half matched) family member donor (parents or siblings)
View Trial

SEDYC: Social and Emotional Development in Children with Cancer

Diseases Treated:

Non-therapeutic

Eligibility:

This is a non-therapeutic research study open only to St. Jude patients, their parents and patients' teachers.

  • Patient between 4 and 6 years old
  • Primary diagnosis of brain tumor or non-CNS solid tumor
  • 6 to 12 months since therapy was completed (+/- 1 month) OR more than 18 months since therapy completion
  • Chemotherapy was part of tumor treatment
  • Able to speak and read English
View Trial

SJMB12: A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma/PNET

Diseases Treated:

Medulloblastoma (includes all variants of medulloblastoma and posterior fossa PNET)

Eligibility:

  • Diagnosis of newly medulloblastoma
  • At least 3 years old and younger than 22 years old (Strata W, S or N) OR
  • At least 22 years old and younger than 40 years old AND has SHH medulloblastoma (Stratum S)
  • Has not received previous treatment with radiation therapy or chemotherapy
  • Must start treatment within 36 days of surgery to remove the tumor
View Trial

SOCFUN: Social Functioning in Survivors of Pediatric Brain Tumors

Diseases Treated:

Brain tumor

Eligibility:

This study is open only to patients at St. Jude Children’s Research Hospital.

  • Diagnosis of medulloblastoma or other brain tumor
  • Between 8 and 12 years old
  • At least 2 years after completion of therapy
  • Full-time student
  • Speaks English
View Trial

TOT17: Total Therapy for Children with Acute Lymphoblastic Leukemia and Lymphoma

Diseases Treated:

Leukemia and lymphoma

Eligibility:

  • Diagnosis of B-cell or T-cell acute lymphoblastic leukemia (ALL) or acute lymphoblastic lymphoma (LLy)
  • 1 to 18 years old
  • No prior therapy or limited prior therapy
View Trial

Collaborative Clinical Trials

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