St. Jude Care & Treatment

Menu

Close

Recruiting

ACNS2321: Response-Based Radiation for Germinoma

About this study

Physician-scientists are studying a new way to treat children and young adults with central nervous system germinoma, a type of brain tumor.

Germinoma treatment usually includes chemotherapy and radiation therapy. This treatment generally effectively cures most of the patients. But radiation therapy to the brain has been linked to certain long-term side effects. These include learning problems and hormonal dysregulation (how the body makes and controls hormones).

ACNS 2321 aims to treat newly diagnosed germinoma patients with lower-dose radiation after chemotherapy. Our goal is to reduce some of the radiation-induced side effects while maintaining survival rates. Patients in this study will get the chemotherapy drugs carboplatin and etoposide to reduce the tumor’s size followed by a lower dose of radiation based on the tumor’s response to chemotherapy.

If the results show that lower-dose radiation is as effective as the standard treatment, it could lead to safer and gentler therapies for children and young adults with germinoma.​

Eligibility overview

  • Newly diagnosed germinoma
  • 3–29 years old

Request a referral

The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.

Overview

Full title:

A Phase II Trial Evaluating Chemotherapy Followed by Response-Based Reduced Radiation Therapy for Patients with Central Nervous System Germinomas

Study goal:

To study carboplatin, etoposide, and lower-dose radiation therapy for germinoma.

Diagnosis:

Germinoma

Age:

3–29 years old

Clinical trials categories:

Germ Cell Tumors (Brain) Brain Tumors

For physicians and researchers

Patients accepted to St. Jude must be referred by a physician or other qualified medical professional. Learn how St. Jude can partner with you to care for your patient.

 

Learn more