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ECHOS2: Heart Health in Childhood Cancer Survivors

About this study 

Many people who had cancer treatment as children have a higher risk of heart problems later in life. Some types of chemotherapy and radiation therapy can hurt the heart over time. Most survivors do not get the regular heart check-ups that doctors recommend, even though those check-ups may help find heart problems sooner. Researchers want to find better ways to help survivors learn about their heart risks and get the right tests. 

The ECHOS2 clinical trial includes survivors of childhood cancer, treated as children, who received treatments that could increase their risk of heart disease. These people have not had a heart ultrasound, called an echocardiogram, in the past several years.   

Participants are randomly placed into 1 of 2 groups. One group gets the usual educational materials about heart screening. The other group also uses an online program called Healthy Hearts. This program includes:  

  • Short videos 
  • Stories from other survivors 
  • An interactive, virtual guide that helps people think through their choices and plan next steps 

The main goal of the trial is to see if people using the Healthy Hearts program go for their heart screening more often than those who only get the usual materials. The study also looks at whether this program can change how people think and feel about getting screened for heart problems. 

There is no direct medical benefit promised to participants, but they may learn more about their heart health and feel more confident making health care decisions. The information learned may help improve care for other survivors in the future. 

Eligibility overview 

  • Adult survivors of childhood cancer who received cumulative doxorubicin equivalent anthracycline doses ≥100 mg/m2 with any/no radiation, or ≥15 Gy chest radiation with any/no anthracyclines 
  • Age 26 years or older  
  • Already enrolled in the Childhood Cancer Survivor Study
  • No known history of cardiomyopathy or heart failure  
  • Have not had a heart ultrasound (echocardiogram) within the past 5 years  
  • Able to complete surveys and online education in English 

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The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.

Overview

Full title:

ECHOS2: Evaluation of Cardiovascular Health Outcomes Among Survivors 2

Study goal:

To study whether an online heart health education and counseling program helps survivors of childhood cancer complete recommended heart screening tests.

Diagnosis:

Childhood cancer

Age:

26 years and older

Clinical trial categories:

Childhood Cancer

For physicians and researchers

Patients accepted to St. Jude must be referred by a physician or other qualified medical professional. Learn how St. Jude can partner with you to care for your patient.

 

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