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FIRECRIT: ICU Risk Markers in Children with Cancer

About this study

Children with cancer who are in the Intensive Care Unit (ICU) often have higher levels of CRP (C-reactive protein) and ferritin in their blood due to their illness. CRP and ferritin are markers that show inflammation in the body. In children without cancer, high levels of these markers can predict if someone is very sick or at risk of dying. But the levels are often already high in children with cancer, so it is harder to tell if the levels mean they are at risk for a worse outcome or if it is just part of their illness.

This study will look at CRP and ferritin levels from leftover blood samples taken during routine care at 3 times:

  • When the child is admitted to the ICU
  • On day 3 of their ICU stay
  • On day 7 of their ICU stay

We will not take any extra blood for the study. Scientists will use this data to figure out cutoff levels for CRP and ferritin that show when a child with cancer is at higher risk for severe illness or death. We will also study other outcomes, like organ problems and how long the child stays in the ICU.

The study will review data from 250 past ICU admissions over 18 months. By finding reliable cutoff levels for CRP and ferritin, we hope to help doctors make better decisions about treatments and avoid unnecessary interventions. This could lead to better care, more targeted treatments, and improved outcomes for children with cancer who are critically ill.Top of Form

Eligibility overview

  • Patients with cancer in the ICU
  • Up to 21 years old

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The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.

Overview

Full title:

FIRECRIT: Ferritin and CRP Cutoffs for Prediction of Mortality in Critically Ill Pediatric Oncology Patients

Study goal:

To study CRP and ferritin levels for predicting ICU mortality and severe illness in critically ill pediatric oncology patients.

Diagnosis:

Childhood cancer

Age:

Up to 21 years

Clinical trials categories:

Childhood Cancer

For physicians and researchers

Patients accepted to St. Jude must be referred by a physician or other qualified medical professional. Learn how St. Jude can partner with you to care for your patient.

 

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