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HAPSAA: Partially Matched Related Donor Bone Marrow Transplant for Patients with Aplastic Anemia

About this study

This is a study to learn more about a type of stem cell transplant in patients with severe aplastic anemia who do not have a matched blood cell donor. A stem cell transplant is also known as a blood cell transplant or a bone marrow transplant.

When a patient needs a blood cell transplant, the first choice of a donor is a matched sibling (brother or sister) donor. When a matched sibling is not available, a matched, unrelated volunteer donor may be used. If none of these donors is available, a family member who is not a full match may be used.

If you participate in this study, you will receive blood cells that have been donated by a half-matched family member and modified in a laboratory at St. Jude. These blood cells are called TCR ab-depleted blood cells. The procedure used to process the blood cells in this study is considered experimental because it has not been approved by the U.S. Food and Drug Administration (FDA).

Once the donor cells have been collected and processed, you will receive radiation and chemotherapy (anti-cancer medicine) to prepare your bone marrow space for the new donor cells. You will be given the donor blood cells through a vein. This procedure is called infusion. These new cells find their way to your bone marrow space and begin to grow and produce new blood cells.

Eligibility overview

  • 21 years old and younger
  • Diagnosis of severe aplastic anemia
  • No available matched donor

The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.


Full title:

Haploidentical Donor Hematopoietic Cell Transplantation for Patients with Severe Aplastic Anemia

Study goal:

The main goal of this study is to learn more about the effects (good and bad) of this treatment in children and young adults with high-risk blood disorders.


Aplastic anemia


21 years old and younger

Clinical trials categories:

Blood Disorders Aplastic Anemia

For physicians and researchers

Patients accepted to St. Jude must be referred by a physician or other qualified medical professional. Learn how St. Jude can partner with you to care for your patient.


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