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VIPER: Predicting Viral Infections After Transplant

About this study

Many children who get bone marrow transplants or organ transplants are at risk of getting infections in their lungs or airways. These infections come from germs  (viruses)  such as respiratory syncytial virus (RSV) and the virus that causes COVID-19. Because children have weaker immune systems after transplant, viral infections can be serious. We want to better predict which children are more likely to get these infections. 

In this study, children who need a bone marrow transplant will get a nasal swab before their transplant to check for virus in their airways. They will also give a blood sample. The researchers will collect another blood sample about 100 days after the transplant. If the child develops a respiratory viral infection in the first year after transplant, more samples will be taken. 

The main goal is to see if the amount of virus found in the nasal swab before transplant, along with their immune function, can predict whether the child will develop a respiratory viral infection within a year after transplant. 

The results will help doctors know which children are at higher risk of serious viral infections after transplant. 

Eligibility overview

  • Under 18 years old
  • Scheduled to get a bone marrow or organ transplant
  • Able to give nasal swab and blood samples before and after the transplant

Request a referral

The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.

Overview

Full title:

VIPER: Multi-Center Molecular Diagnosis and Host Response of Respiratory Viral Infections in Pediatric Transplant Recipients 

Study goal:

To study respiratory viruses in transplant patients to predict infection risk and improve care

Diagnosis:

Childhood cancer, Blood disorders, Immune disorders, Genetic syndromes

Age:

0–17 years

Clinical trial categories:

Childhood Cancer Blood Disorders Immune Disorders Genetic Syndromes

For physicians and researchers

Patients accepted to St. Jude must be referred by a physician or other qualified medical professional. Learn how St. Jude can partner with you to care for your patient.

 

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