Infectious Diseases Clinical Trials

Full title:

ATN173: Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections Among Adolescent and Young Adult Females in the United States

Study goal:

To study whether giving the antibiotic doxycycline can prevent gonorrhea, chlamydia, or early syphilis among adolescent and young adult females

Diagnosis:

Gonorrhea, Chlamydia, Syphilis, Bacterial Sexually Transmitted Infections (STIs)

Age:

13-29 years

Full title:

BUGBANK: Infection Research Specimen Biorepository Protocol

Study goal:

To collect and store leftover infection samples and related data to support future infectious disease research.

Diagnosis:

Infectious diseases

Age:

All ages

Full title:

EXPRESSIVE11: A Phase 3, Randomized, Active-Controlled, Double-blind Clinical Study to Evaluate the Efficacy and Safety of MK-8527 Oral Once-monthly as HIV-1 Preexposure Prophylaxis

Study goal:

To study MK-8527 and compare it to emtricitabine/tenofovir (FTC/TDF) for HIV-1 prevention

Diagnosis:

HIV-1 infection prevention

Age:

16 years and older

Full title:

GS5578: A Phase 1b Study to Evaluate the Safety and Pharmacokinetics of Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF) in Neonates Exposed to HIV-1

Study goal:

To study if Biktarvy® is safe for newborns who were born to mothers living with HIV, how this medicine moves through the body, and what dose works best.

Diagnosis:

HIV

Age:

Up to 120 hours at enrollment

Full title:

IDEAL: Immune Development in Early Life

Study goal:

To learn more about how exposure to respiratory infections as an infant or young child can impact the immune system.

Diagnosis:

Healthy volunteer

Age:

Under 3 years old

Full title:

IMPAACT2046: Understanding Practices of Lactation and Infant Feeding Together with Women with HIV in the United States 

Study goal:

To understand infant feeding decisions, practices, and health outcomes for women with HIV and their babies in the United States.

Diagnosis:

Human immunodeficiency virus (HIV)

Age:

Women: 18 years and older
Infants: Newborns of enrolled mothers may be included in some parts of the study

Full title:

PGEN5: Pharmacogenetic Determinants of Treatment Response in Children

Study goal:

To study genetic (pharmacogenetic) differences in how people process and respond to drugs (agents) in children with childhood cancer or other life-threatening conditions

Diagnosis:

Childhood cancer, Blood disorders, Immune disorders, Infectious diseases, Neurological disorders, Genetic syndromes

Age:

Children and adults

Full title:

A Randomized, Double-Blind, Controlled, Parallel Group Study with the INTERCEPT® Blood System for Red Blood Cells in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections (RedeS Study) and Treatment Use Open-Label Extension Study

Study goal:

To study the safety and use of red blood cells prepared with the INTERCEPT® Blood System for Red Blood Cells as compared with red blood cells that are not prepared with this system.  

Diagnosis:

Sickle Cell Disease, Sickle Cell Anemia, Blood Disorders

Age:

Ages 4 and up

Full title:

SNIFF: Determinants of Disease Severity in Influenza Infection

Study goal:

To learn more about why some children and young adults get very sick with flu while others do not.

Diagnosis:

Flu or suspected flu

Age:

Less than 30 years old

Full title:

TBANK: Protocol for Collecting, Banking, and Distributing Human Tissue Samples: St. Jude Children’s Research Hospital Biorepository

Study goal:

To provide a high-quality repository of tumor and normal samples to facilitate translational research performed by St Jude faculty and their collaborators

Diagnosis:

All diseases

Full title:

VSTHCT: Haploidentical Viral-Specific T-Cells for Treatment of Cytomegalovirus and Adenovirus Infections after Hematopoietic Cell Transplantation

Study goal:

To study virus-specific T-cells for treating cytomegalovirus and adenovirus infections after hematopoietic cell transplantation

Diagnosis:

Childhood cancer, blood disorders, genetic syndromes, immune disorders, infectious diseases

Age:

Up to 18 years