Medulloblastoma: It’s Not Just a Child’s Disease

Patients Richard and Sahasra sitting in a window sill.

Medulloblastoma is the most common malignant brain tumor in children, but it is also sometimes found in young adults.

St. Jude is a leader in developing innovative, personalized treatments for medulloblastoma and other brain tumors. While most of our clinical trials are for children, we are currently enrolling patients up to 39 years old with sonic hedgehog (SHH) medulloblastoma for the following studies:

SJMB12

About the study:

This Phase II study  offers radiation and chemotherapy for patients with newly diagnosed medulloblastoma. Treatment is tailored to each patient’s clinical risk and the tumor’s molecular type. The main goal of the trial is to offer a targeted agent specific to SHH medulloblastoma.

There are several parts, or strata, to this study. Adults with standard- or high-risk SHH medulloblastoma tumors may be eligible for Stratum S.

Eligibility overview for Stratum S:

  • Newly diagnosed with SHH medulloblastoma
  • Skeletally mature up to 39 years old (Contact St. Jude with questions about skeletal maturity.)
  • No previous treatment with radiation therapy or chemotherapy

SJDAWN

About the study:

This Phase I study  tests new drug combinations for patients with tumors that did not respond to prior treatment or whose tumors came back after therapy. The main goal of the study is to determine the highest dose of these medicines that can be given safely to patients.

Adults with SHH tumors may be eligible for Stratum C of the trial. This stratum targets tumors with a chemotherapy combination of two drugs called ribociclib and sonidegib. The U.S. Food and Drug Administration (FDA) drugs has approved these drugs to treat other cancers in adults. However, they have not approved the drugs to treat brain tumors or any other cancers in children.

Eligibility overview for Stratum C:

  • Diagnosed with recurrent, progressive, or refractory SHH medulloblastoma 
  • Skeletally mature up to 39 years old (Contact St. Jude with questions about skeletal maturity.)

Please contact St. Jude below to learn more about eligibility for either of these clinical trials.

Contact

Tabatha E. Doyle, RN
Coordinator, Brain Tumor Program
MS 260
262 Danny Thomas Place
Memphis, TN 38105
Phone: (901) 595-2544

Brain Tumor Contact Form

For updates on COVID-19, please read.