Cancer Center Members

    Department of Anesthesiology
    Research interests: pain management, anesthesia risks, palliative care

    Department of Epidemiology & Cancer Control
    Research interests: pediatric neuro-oncology and cancer survivorship

    Department of Tumor Cell Biology
    Research interests: applications of flow cytometry and cell separation

    Department of Pathology
    Research interests: Pediatric bone and soft tissue tumors

    Co-Leader, Neurobiology and Brain Tumor Program
    Department of Developmental Neurobiology
    Research interests: PTEN and key signaling pathways in brain tumors

    Director, Transgenic / Gene Knockout Shared Resource

  • Department of Surgery
    Research interests: brain tumor clinical trials; functional neuro-imaging in children; advanced surgical techniques in children

    Department of Oncology
    Research interests: retinoblastoma therapy and late effects, translating preclinical research into clinical trials, Phase I clinical trials, complications of chemotherapy

    Department of Epidemiology & Cancer Control
    Research interests: Psychosocial outcomes of childhood cancer

    Department of Oncology
    Research interests: biology and treatment of high-grade gliomas

    Department of Developmental Neurobiology
    Research interests: growth control during neural tube development

    Department of Pediatric Medicine
    Research interests: late effects observed in childhood cancer survivors

    Department of Chemical Biology & Therapeutics
    Research interests: small-molecule transcription factor drug discovery

    Department of Biostatistics
    Research interests: statistical methods in cancer genomics and genetics

    Department of Immunology
    Research interests: cellular signaling in innate and adaptive immunity

    Department of Pathology
    Research interest: To understand the mechanisms by which the transcription factor E2A regulate normal and leukemic precursor B cell proliferations

    Director, Government Affairs

    Department of Hematology
    Research interests: vascular/hematopoietic development and leukemia

    Department of Psychology
    Research interests: cognitive outcomes of childhood cancer treatment

    Department of Bone Marrow Transplantation & Cellular Therapy
    Research interests: development of novel immunomodulatory therapies

    Department of Genetics
    Research interests: intracellular degradation in development and disease

    Department of Surgery
    Research interests: angiogenesis inhibition for cancer therapy

    Department of Developmental Neurobiology
    Research interests: Mechanisms of skeletal muscle aging, protein homeostasis, and myokines

    St. Jude President and Chief Executive Officer
    Department of Pathology
    Research interests: the molecular pathology of acute leukemia

    Co-Leader, Developmental Biology and Solid Tumor Program
    Department of Developmental Neurobiology
    Research interests: retinal development and retinoblastoma

    Department of Pathology
    Research interests: pathologic/molecular classification of CNS tumors

    Department of Structural Biology
    Research interests: Molecular mechanisms of DNA replication

    Department of Pharmaceutical Sciences
    Research interests: pharmacogenomics of antileukemic agents in children

    Department of Oncology
    Research interests: biology and clinical investigation of pediatric soft tissue tumors; translational research and novel drug development of pediatric solid malignancies

  • Sharon Frase

    Frase

    Director of Electron Microscopy, Cell & Tissue Imaging Center

    Department of Oncology
    Research interest: genetic interactions that give rise to neuroblastoma; preclinical models of neuroblastoma

    Director of Light Microscopy, Cell & Tissue Imaging Center 

    Department of Chemical Biology & Therapeutics
    Research interests: medicinal chemistry, chemical biology, PDZ domain

    Department of Oncology
    Research interests: new drug development, neuroblastoma, liver tumors

    Co-Leader, Neurobiology and Brain Tumor Program
    Department of Oncology
    Research interests: novel treatments for children with brain tumors

    Department of Oncology
    Research Interests: Cellular and genetic origins of childhood cancers

    Department of Epidemiology and Cancer Control
    Research interests: Risk factors for late effects after pediatric cancer

    Department of Epidemiology and Cancer Control
    Research interests: Late effects of treatment for childhood cancer, particularly fertility and pregnancy outcome, and late effects of treatment for Wilms tumor.

    Co-Leader, Cancer Biology Program
    Department of Immunology
    Research interests: apoptosis, autophage and mitochondria

    Director, Pediatric Oncology Education (POE) Program

  • Department of Genetics
    Research interests: the role of chromosome translocations in cancer

    Department of Oncology
    Research interests: molecular pathology of infantile leukemia

    Department of Developmental Neurobiology
    Research interests: Primary cilia in brain development and tumorigenesis

    Department of Diagnostic Imaging
    Research interests: Development of novel MR contrast mechanisms and their application to the study of pediatric brain tumors and CNS treatment sequelae

    Department of Oncology
    Research interests: Cellular and molecular origins of rhabdomyosarcoma

    Department of Diagnostic Imaging
    Research interests: cerebral perfusion and white matter connectivity

    Department of Tumor Cell Biology
    Research interests: ER quality control in development and disease

    Department of Cell and Molecular Biology
    Research interests: Regulation of transcription and enhancer activity by chromatin-modifying proteins

    Department of Epidemiology and Cancer Control
    Research interests: Patient-reported outcomes measurement for childhood cancer

    Co-Leader, Cancer Prevention and Control Program
    Department of Oncology
    Research interests: health outcomes after childhood cancer

    Department of Oncology
    Research Interests: novel therapies for leukemia/lymphoma, especially acute myeloid leukemia and lymphoblastic lymphoma

    Department of Oncology
    Research interests: childhood leukemias, developmental therapeutics

    Department of Immunology
    Research interests: mechanisms of host defense and inflammation

    Comprehensive Cancer Center
    Research interests: prevention of toxicity during acute leukemia therapy

    Department of Diagnostic Imaging
    Research interests: skeletal toxicities in childhood cancer survivors

    Department of Pathology
    Research interests: Genomic and functional characterization of acute myeloid leukemia

    Department of Psychology
    Research interests: men's and women's health in cancer survivorship

    Department of Radiological Sciences
    Research interests: developing local therapy strategies for sarcomas

  • Department of Structural Biology
    Research interests: structural basis of tumor suppressor function

    Department of Epidemiology and Cancer Control
    Research interests: The neurocognitive outcomes and late effects of childhood cancer, as well as using biologic and psychosocial moderators/mediators of these effects to design interventions for deficits in attention, memory, and executive functions

    Department of Pathology
    Research Interests: Mechanisms involved in mitochondrial clearance and links to hematopoietic malignancies

    Department of Developmental Neurobiology
    Research interests: role of platelets in cancer metastasis

    Department of Oncology
    Research interests: international outreach, solid tumors, improving adolescent outcomes

    Department of Oncology
    Research interests: Development of new chemotherapeutic agents

    Department of Tumor Cell Biology
    Research interests: Genome editing in cancer development

    Division of Nursing Research
    Research interests: Mechanisms of cancer related symptoms

    Department of Diagnostic Imaging
    Research interests: solid tumor imaging and contrast-enhanced sonography

    Department of Hematology
    Research interests: Cellular and molecular regulation of hematopoietic stem cell in vivo repopulating activity

  • Department of Genetics
    Research interests: DNA damage responses in the nervous system

    Department of Radiation Oncology
    Research interests: medulloblastoma, ependymoma, craniopharyngioma, low-grade glioma

    Department of Oncology
    Research interests: Hodgkin and non-Hodgkin lymphomas, leukemias, IOP

    Department of Structural Biology
    Research interest: structure/function relationship of dynamic and disordered protein complexes in signal transduction

    Department of Chemical Biology & Therapeutics
    Research interests: programmed cell death in health and disease

    Department of Developmental Neurobiology
    Research interests: control of neuronal death and differentiation

    Co-Leader, Hematologic Malignancies Program
    Department of Pathology
    Research interests: genomic profiling of acute leukemia

    Department of Oncology
    Research interests: cardiovascular outcomes of cancer therapy

    Department of Infectious Diseases
    Research interests: control of inflammatory responses

    Administrative Director, Genomics

    Department of Epidemiology & Cancer Control
    Research interests: functional limitations among cancer survivors

    Department of Developmental Neurobiology
    Research Interests: Integrative genomics and molecular features of pediatric brain tumors

    Department of Pathology
    Research interests: metabolic regulation of apoptosis; calcium homeostasis during apoptosis; metabolic regulation of ER stress

    Department of Cell & Molecular Biology
    Research Interest: mechanisms of Hedgehog signal transduction in development and disease

    Department of Diagnostic Imaging
    Research interests: brain function of survivors of childhood diseases

  • Arzu Onar-Thomas, PhD

    Onar-Thomas

    Department of Biostatistics
    Research interests: Ph I-II designs, bioinformatics, survival analysis

    Department of Cell & Molecular Biology
    Research interests: regulation of cell death during hematopoiesis

    Department of Pathology
    Research interests: molecular classification of tumors of the nervous system

    Co-Leader, Developmental Biology and Solid Tumor Program
    Department of Oncology
    Research Interests: Development of novel therapies for pediatric solid tumors with special interest in: pediatric melanoma; soft tissue sarcomas; pediatric gastrointestinal stromal tumors

    Department of Pathology
    Research interests: chromosome segregation, heterochromatin assembly

    Department of Diagnostic Imaging
    Research interests: multimodality tumor tissue characterization by MRI

    Department of Structural Biology
    Research interests: Proteomics to ubiquitin biology and human disease

    Department of Psychology
    Research interests: coping and adjustment in children with cancer

    Department of Chemical Biology & Therapeutics
    Research interests: anticancer drug hydrolysis by carboxylesterases

    Department of Cell & Molecular Biology
    Research interests: Higher-order regulation of autophagy 

    Department of Cell & Molecular Biology
    Research interests: Molecular mechanisms of tumorigenesis

    Department of Biostatistics
    Research interests: develop statistical methods for genomics studies

  • Co-Leader, Hematologic Malignancies Program
    Department of Oncology
    Research interests: biology and treatment of childhood leukemia

    Department of Oncology
    Research interests: low grade gliomas as unique diseases; advancing study of pediatric brain tumors in developing countries through international collaboration, twinning, and telemedicine

    Animal Resource Center

     

    Department of Diagnostic Imaging
    Research interests: white matter injury and neurocognitive functioning

    Department of Pharmaceutical Sciences
    Research interests: pharmacokinetics and genetics of leukemia therapy

    Department of Oncology
    Research interests: hematological malignancies

    Director, Comprehensive Cancer Center
    Department of Oncology
    Research interest: SWI/SNF (BAF) chromatin remodeling/tumor suppressor
     

    Department of Oncology
    Research interests: Origin and genomics of medulloblastoma, translational studies

    Associate Director, Cancer Prevention & Control
    Co-Leader, Cancer Prevention & Control Program
    Department of Epidemiology & Cancer Control
    Research interests: pediatric cancer epidemiology and outcomes

    Department of Infectious Diseases
    Research interests: membrane phospholipid metabolism

  • Carlos Rodriguez-Galindo, MD

    Rodriguez-Galindo

    Associate Director, Outreach
    Department of Global Medicine
    Research interests: Global medicine; pediatric solid tumors

    Co-Leader, Cancer Biology Program
    Department of Tumor Cell Biology
    Research interests: genes and microRNAs in brain tumors

  • Department of Oncology
    Research interests: treatment of acute myeloid leukemia

    Department of Diagnostic Imaging
    Research interests: the imaging of brain tumors and neuroimaging of long-term survivors of childhood cancer

    Department of Diagnostic Imaging
    Research interests: mathematical models of cancer behavior, imaging-based tumor biomarkers, and phase-transitions in cancer biology

    Department of Oncology
    Research interests: clinical and biologic investigation of NHL and ALL

    Associate Director, Clinical Research
    Department of Oncology
    Research interests: novel therapeutics, neuroblastoma, research ethics

    Department of Pharmaceutical Sciences
    Research interests: mechanisms of human variation in drug response

    Department of Pharmaceutical Sciences
    Research interests: regulation and function of ABC transporters

    Department of Structural Biology
    Research interests: cellular regulation by ubiquitin-like proteins

    Department of Chemical Biology & Therapeutics
    Research interests: Multi-scale modeling of biological and chemical data

  • Department of Tumor Cell Biology
    Research interests: tumor suppressor-dependent signaling networks

    Department of Diagnostic Imaging
    Research interests: PET CT imaging and evaluation of pediatric tumors

    Vice President for Scientific Operations

    Departments of Diagnostic Imaging and Chemical Biology & Therapeutics
    Research interests: design of radioactive drugs for medical imaging

    Department of Developmental Neurobiology
    Research interests: cell polarity in neuron precursor differentiation

    Department of Hematology
    Research interests: gene therapy and hematopoietic stem cell biology

    Department of Bone Marrow Transplant & Cellular Therapy
    Research interests: infections in the immune-compromised host

    Department of Biostatistics
    Research interests: clinical trials, robust methods, survival analysis

    Department of Pharmaceutical Sciences
    Research interests: pharmacology of anticancer drugs in children

    Department of Oncology
    Research interests: high risk pediatric solid tumors

    Director, Diagnostic Biomarkers Shared Resource

    Associate Director, Basic Research
    Department of Cell & Molecular Biology
    Research interests: To understand the roles of catabolic pathways

    Department of Immunology
    Research interests: Innate and adaptive immunity to influenza

    Department of Radiation Oncology
    Research interests: brain tumors and sarcomas

    Department of Bone Marrow Transplantation & Cellular Therapy
    Research interests: Hematopoietic cell transplant for high risk leukemia; Use of alternative donors in patients lacking a fully matched sibling donor; Immune reconstitution following hematopoietic cell transplant

  • Marc Valentine

    Valentine

    Director, Cytogenetics Shared Resource

    Associate Director, Administration

    Department of Hematology
    Research interests: blood development and associated diseases

    Department of Structural Biology
    Research interests: structural analysis of catalysis and DNA repair

    Department of Epidemiology & Cancer Control
    Research interests: Late effects of childhood cancer therapy

  • Department of Surgery
    Research interests: surgical ophthalmology

    Department of Biostatistics
    Research interests: design and analysis of preclinical and clinical trials

    Department of Pharmaceutical Sciences
    Research interests: the genomics of hematologic tumors, with particular interests in genomic characterization of inter-patient variability in anti-leukemia drug response and disease susceptibility

    Department of Immunology
    Research interests: T-cell memory differentiation and exhaustion

    Department of Developmental Neurobiology
    Research interests: synaptic and neuronal mechanisms of schizophrenia

    Associate Director, Education and Training
    Department of Biochemistry
    Research interests: p53 function in tumor suppression and tumorigenesis

    Department of Computational Biology
    Research interest: computational methods for cancer genomics

    Department of Pharmaceutical Sciences
    Research interests: stem cells in normal and malignant development

    Department of Developmental Neurobiology
    Research interests: hair cell function and regeneration in mice