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EAYAHCT: Building Strength and Fitness after Transplant

About this study

Some young people who have had bone marrow (stem cell) transplants may lose muscle strength and energy. This can make it harder to do everyday activities and feel healthy. Doctors and researchers want to find ways to help survivors rebuild their strength and fitness. This study will test if exercise and a supplement called nicotinamide riboside (NR) can help improve muscle strength and energy after transplant.

This study is for people who had bone marrow transplant 6 to 48 months ago. They may have had acute lymphoblastic leukemia, acute myesukemia, myelodysplastic syndrome, or aplastic anemia before their transplant. The study will last about 16 weeks.

Each person will be randomly placed into 1 of 4 groups. They will either: 

  • Exercise and take NR 
  • Exercise and take a placebo (a pill that looks real but has no active medicine) 
  • Take NR without exercise 
  • Take a placebo without exercise

The exercises can be done at home with help from trained coaches. St. Jude provides the exercise equipment. Patients will wear fitness trackers to monitor their heart rate and physical activity. They will also have blood draws, exercise testing, and MRI and bone density scans.

The research team will measure: 

  • How strong each person’s muscles are before and after the study
  • How much muscle they have
  • How fit their heart and lungs are
  • How well their muscles make energy 

These tests will help show if exercise, NR, or both together can make a difference in strength and fitness after bone marrow transplant.

Researchers hope this study will show safe and effective ways to help young people recover after bone marrow transplants. Building back muscle and energy could improve long-term health and make it easier for survivors to stay active as they grow older. The results may help doctors design better programs for patients in the future.

Eligibility overview

  • 10–30 years old
  • Had acute leukemia, myelodysplastic syndrome, or aplastic anemia 
  • Had a bone marrow transplant 6–48 months ago
  • Healthy enough to exercise

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The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.

Overview

Full title:

EAYAHCT: Intensive Tailored Exercise Training With NAD+ Precursor Supplementation to Improve Muscle Mass and Fitness in Adolescent and Young Adult Hematopoietic Cell Transplant Survivors

Study goal:

To study if exercise and nicotinamide riboside improve muscle strength and energy in young bone marrow transplant survivors.

Diagnosis:

Acute lymphoblastic leukemia (ALL), Acute myeloid leukemia (AML), Myelodysplastic syndrome, Aplastic anemia

Age:

10–30 years

Clinical trial categories:

Blood Disorders Acute Myeloid Leukemia (AML) Childhood Cancer Aplastic Anemia Myelodysplastic Syndromes Acute Lymphoblastic Leukemia (ALL)

For physicians and researchers

Patients accepted to St. Jude must be referred by a physician or other qualified medical professional. Learn how St. Jude can partner with you to care for your patient.

 

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