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ORIOME: Mouth and Nose Microorganisms in Childhood Cancer Patients

About this study

The human body is home to many tiny organisms such as bacteria, fungi and viruses. These organisms live in all parts of the body, including the nose and mouth. Scientists call this collection of tiny organisms the human microbiome.

Antibiotics and strong anti-cancer medicines, known as chemotherapy, change the microbiomes of cancer patients. This study will examine mycobiome changes in the noses and mouths of young cancer patients receiving chemotherapy or stem cell transplant at St. Jude Children’s Research Hospital.

Eligibility overview

This is a non-therapeutic clinical trial that is only open to St. Jude patients.

  • Between 4 and 21 years old
  • Newly confirmed diagnosis of acute myeloid leukemia (AML) or scheduled to receive conditioning for allogeneic hematopoietic stem cell transplantation within seven days
  • Receiving treatment at St. Jude Children’s Research Hospital

The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.


Full title:

The Oronasal Microbiota in Pediatric Oncology Patients

Study goal:

The main purpose of this study is to learn more about the changes that occur in the mycobiome of the mouth and nose as a result of receiving cancer therapy.


Between 4 and 21 years old

For physicians and researchers

Patients accepted to St. Jude must be referred by a physician or other qualified medical professional. Learn how St. Jude can partner with you to care for your patient.


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