About this study
Children who are treated for serious illnesses often need strong medicines. But not every child reacts the same way to these medicines. Some children may have side effects, some may respond very well, and others may not benefit. Research shows that our genes play a big role in how our bodies handle medicines. By studying these genes, doctors hope to give the right dose of medicine and prevent harmful side effects in the future.
The goal of this study is to see how genes affect treatment response—how a child’s body processes, responds to, or is harmed by medicine. Understanding this can help doctors make treatment safer and more effective for each child.
In this study, researchers will collect a small blood sample, about 1 teaspoon, from patients. The blood will be used to look at genetic material called DNA and RNA. The samples will help scientists understand how genes affect the way medicines work. The blood sample is usually taken at the same time as other routine tests, so patients will not need extra needle sticks.
Family members and non-patient volunteers may also give blood samples so scientists can compare genetic patterns across related and unrelated people. This helps identify which gene changes are linked to differences in how medicines work or cause side effects.
At the end of the study, researchers want to learn which gene changes influence how children respond to treatment. That knowledge could help doctors choose medicines and doses that are safer and work better for each child. The ultimate goal is more personalized care, fewer harmful side effects, and better outcomes for children receiving treatment.
Eligibility overview
- Children and adults
- Patients with childhood cancer, blood disorders, immune disorders, infectious diseases, neurological disorders, and genetic syndromes
- Family members and non-patient volunteers
- Willing to have blood drawn for genetic testing