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VSTHCT: Virus-specific T-cells for CMV and ADV Infection

About this study

This clinical trial is studying a new treatment for children and young adults who have had a bone marrow transplant (also called a stem cell transplant or hematopoietic cell transplant). Some patients who have these transplants get serious viral infections. Two common viruses are:

These infections can make patients very sick or even die. The infections can be hard to treat with regular antiviral medicines.

The VSTHCT study tests virus-specific T-cells (VSTs). These are special immune cells that are taken from a donor and given to the patient. The goal is for these cells to help the patient fight off the CMV and ADV infections.  

We hope to learn if VSTs can safely lower virus levels. We also want to see if the treatment works for at least 3 months and if it helps the patient stay healthy for 6 months or longer.

This trial is needed because patients who have transplants have weak immune systems. Antiviral medicines do not always work for them. Using VSTs may give patients a stronger defense against these infections.

If this trial works, it could give doctors a new way to treat patients after a transplant. This could help patients recover faster, stay healthier, and have fewer problems from viral infections.

Eligibility overview

  • Up to 18 years old
  • Had a bone marrow transplant
  • Has an active cytomegalovirus (CMV) or adenovirus (ADV) infection
  • Able to receive virus-specific T-cell therapy safely
  • Has adequate organ function

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The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.

Overview

Full title:

VSTHCT: Haploidentical Viral-Specific T-Cells for Treatment of Cytomegalovirus and Adenovirus Infections after Hematopoietic Cell Transplantation

Study goal:

To study virus-specific T-cells for treating cytomegalovirus and adenovirus infections after hematopoietic cell transplantation

Diagnosis:

Childhood cancer, blood disorders, genetic syndromes, immune disorders, infectious diseases

Age:

Up to 18 years

Clinical trials categories:

Blood Disorders Infectious Diseases Childhood Cancer Immune Disorders Genetic Syndromes

For physicians and researchers

Patients accepted to St. Jude must be referred by a physician or other qualified medical professional. Learn how St. Jude can partner with you to care for your patient.

 

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