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Non-Hodgkin Lymphoma Treatment

Also called: Non-Hodgkin’s lymphoma, NHL

Non-Hodgkin lymphoma is a form of cancer that affects the lymphatic system, part of the body’s immune system. It is a group name for all lymphomas except Hodgkin lymphoma.

White blood cells called lymphocytes help to fight infection in healthy people. In people with non-Hodgkin lymphoma, these lymphocytes develop an error and begin to grow out of control.

The cancer can begin anywhere in the lymphatic system (lymph nodes, bone marrow, spleen, or tonsils for example) and can spread to the other parts of the lymphatic system or other places in the body like the liver, lungs, or bones.

The survival rate for non-Hodgkin lymphoma in children in the United States is about 90% (9 in 10).

Find out more about non-Hodgkin lymphoma on the Together by St. Jude™ online resource.

Non-Hodgkin lymphoma treatment

Chemotherapy (“chemo”) is the most common treatment for non-Hodgkin lymphoma.

Treatment methods may include:

Non-Hodgkin lymphoma clinical trials

St. Jude offers clinical trials and cancer research studies for children, teens, and young adults for non-Hodgkin lymphoma. Learn more about clinical research at St. Jude.  

PEPN2011: Tegavivint Treatment for Solid Tumors, Lymphomas, and Desmoid Tumors

Study goal:

The main purpose of this study is to find out how well the medicine tegavivint works to help children, teens, and young adults with certain recurrent or refractory solid tumors.


12 months to 30 years

REF2HCT: Haploidentical Bone Marrow Transplant for Relapsed or Refractory Leukemia, Lymphoma, or Myelodysplastic Syndrome After an Earlier Transplant

Study goal:

The main goal of this study is to learn about the good and bad effects of transplanting blood cells donated by a family member to children and young adults with cancer that has come back or did not improve after a previous bone marrow transplant.


21 years old and younger

Non-Hodgkin lymphoma care at St. Jude 

St. Jude provides the highest quality of care for patients with non-Hodgkin lymphoma:

  • Scientists work with doctors to learn more about how non-Hodgkin lymphoma develops. For example, researchers at St. Jude found that inherited changes (mutations) in the BRCA2 gene were linked with an increased risk of non-Hodgkin lymphoma in children and teens. Our staff has also led the way to understanding which long-term side-effects patients treated with current therapies are potentially at risk for. 

  • St. Jude offers a dedicated team of specialists to meet the needs of children with cancer, including:

    • Surgeons, doctors, and nurses who treat this cancer
    • Doctors who specialize in radiation therapy and pathology (making a diagnosis by looking at tumor tissue under the microscope)
    • Experts in diagnostic imaging and nuclear medicine
    • Genetic counselors
    • Clinical dietitians
    • Child life specialists
    • Psychologists
    • Researchers and scientists

More reasons to choose St. Jude for care include:

  • We are consistently ranked among the best childhood cancer centers in the nation by US News & World Report. 

  • At St. Jude, we have created an environment where children can be children and families can be together.  

  • We lead more clinical trials for childhood cancer than any other hospital in the U.S.  

  • St. Jude is the only National Cancer Institute–designated Comprehensive Cancer Center just for children. A Comprehensive Cancer Center meets rigorous standards for research that develops new and better approaches to prevent, diagnose, and treat cancer. 

  • The nurse-to-patient ratio at St. Jude is about 1:3 in hematology and oncology and 1:1 in the Intensive Care Unit. 

  • Patients may be able to get expert, compassionate care and treatment closer to their homes through the St. Jude Affiliate Program. 

A statue of children running and holding hands

Seeking treatment at St. Jude

Patients accepted to St. Jude must have a disease we treat and must be referred by a physician or other qualified medical professional. We accept most patients based on their ability to enroll in an open clinical trial.

How to seek treatment

Contact the Physician / Patient Referral Office

Call: 1-888-226-4343 (toll-free) or 901-595-4055 (local)  | Fax: 901-595-4011 | Email: | 24-hour pager: 1-800-349-4334


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