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SCCRIP: Sickle Cell Research and Intervention Program

The Sickle Cell Clinical Research and Intervention Program (SCCRIP) is a multi-center clinical trial studying the issues that sickle cell disease patients experience over time. St. Jude scientists want to know how sickle cell disease progresses throughout patients’ lives. Researchers also want to learn about the health and social effects of the disease and the long-term effects of certain treatments.

About this study

Since 2014, SCCRIP has collected information from more than 1,600 sickle cell disease patients treated in hospitals across the Southeast and Midwest United States. Thanks to our participants and their families, we have been able to advance sickle cell disease research. What we learn from SCCRIP helps us develop care guidelines and create better treatments.

Information for participants

By taking part in SCCRIP, you can help us learn more about the effects of sickle cell disease on patients throughout their lifetimes. Learn more about the type of information we collect.

Latest results of SCCRIP

Read the latest results from SCCRIP and what this means for the future of treatment for patients with sickle cell disease.

Cohort study

SCCRIP is a cohort study. A cohort study is a type of medical research that explores the causes and effects of disease. Cohort studies also find links between life-threatening factors and patients’ quality of life. The word “cohort” means a group of people. These studies look at groups of people who have had similar issues within a certain time period.

The people who take part in SCCRIP share a common history of diagnosis and treatment for sickle cell disease.

Identifying late effects

Late effects are health problems that continue or develop later in life. Late effects are linked to the progression of sickle cell disease and/or to the treatments patients received.

SCCRIP collects health information throughout each participant’s lifespan. Details gained from this study help us better understand how sickle cell disease progresses. It also shows us how treatments affect long-term health.

DNA banking

The study’s research includes optional DNA banking. This process stores blood, urine, saliva, stool, and other material for use in future genetic studies. The genetic studies are designed to help us better understand sickle cell disease. You can opt out of this portion and still take part in the SCCRIP study.

Contact SCCRIP

If you are not yet in this study but would like to join, email us at

If you take part in SCCRIP, please update your contact information in MyChart so we can stay connected. The SCCRIP research team wants to share with you what we learn about sickle cell disease.

Mailing address
St. Jude Children's Research Hospital
Department of Hematology
262 Danny Thomas Place, MS 800
Memphis, TN 38105-3678

The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.


Full title:

Sickle Cell Research and Intervention Program

Study goal:

The purpose of this research study is to collect data on sickle cell disease participants from birth to end of life. With these data, researchers will better understand problems caused by sickle cell disease both in children and in adults. 

For physicians and researchers

Patients accepted to St. Jude must be referred by a physician or other qualified medical professional. Learn how St. Jude can partner with you to care for your patient.


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