Diseases Treated by Stem Cell Transplant

Many malignant and non-malignant disorders can be treated with bone marrow/stem cell transplants. High-dose chemotherapy followed by an autologous transplant is typically used for patients with high-risk solid tumors, lymphomas and acute myeloid leukemia. Stem cell collection for these patients is ideally performed when bone marrow contains minimal or no malignancy.
Diseases treated by autologous stem cell transplant include:

  • acute myeloid leukemia (AML)
  • brain tumors
  • Ewing sarcoma
  • germ cell tumors
  • Hodgkin lymphoma
  • neuroblastoma
  • non-Hodgkin lymphoma (NHL)
  • retinoblastoma
  • rhabdomyosarcoma
  • Wilms tumor

Allogeneic hematopoietic stem cell transplant has been successful as a treatment for various malignant and non-malignant disorders.
Malignant disorders treated by this method include:

  • acute lymphoblastic leukemia (ALL)
  • acute myeloid leukemia (AML)
  • juvenile myelomonocytic leukemia (JMML)
  • myelodysplastic syndrome (MDS)
  • non-Hodgkin lymphoma (NHL)
  • high-risk solid tumors, under certain circumstances.

Non-malignant disorders treated with this method include:

  • bone marrow failure syndromes
  • chronic granulomatous disease
  • Fanconi anemia
  • metabolic storage disorders
  • osteogenesis imperfecta
  • osteopetrosis
  • severe aplastic anemia
  • severe combined immunodeficiency syndrome (SCID)
  • sickle cell anemia
  • thalassemia
  • Wiskott-Aldrich syndrome