Genetic counseling and testing proposed for patients with the brain tumor medulloblastoma
Researchers created the first genetic screening guidelines for medulloblastoma patients after identifying gene variations that make carriers susceptible.
Discovery of likely subtypes of rare childhood brain tumor signals diagnostic advance
Molecular classification of rare brain tumors CNS-PNET likely to improve diagnosis and set stage for targeted therapies.
Study finds significant cognitive impairment in adult survivors of childhood brain tumors
St. Jude LIFE study reports that decades after treatment, adult survivors of childhood brain tumors often face significant cognitive challenges.
Researchers mine the epigenome to identify likely origins of childhood brain tumor subtype
Epigenome yields insights into medulloblastoma, the most common malignant pediatric brain tumor, including likely cell of origin for Group 4 subtype.
Targeted therapy shows effectiveness against a subtype of the brain tumor medulloblastoma
A subset of medulloblastoma tumors briefly stopped growing or disappeared during treatment with the targeted drug vismodegib.
Eighteen genes identified that contribute to childhood brain tumor ependymoma
St. Jude discovery lays the foundation for developing new chemotherapy agents and finds evidence that statins slow growth of ependymoma tumor cells.
First cancer-promoting oncogenes discovered in rare brain tumor of children and adults
Researchers have identified three genes that play a pivotal role in the brain tumor choroid plexus carcinoma (CPC), a discovery that lays the groundwork for more effective treatment of this rare, often fatal cancer.
Gene sequencing project discovers mutations tied to deadly brain tumors in young children
St. Jude Children’s Research Hospital-Washington University Pediatric Cancer Genome Project offers new leads to improved outcomes for children with high-grade glioma brain tumors; particularly youngest patients.
Gene sequencing project discovers common driver of a childhood brain tumor
St. Jude Children’s Research Hospital -Washington University Pediatric Cancer Genome Project identifies the most common genetic alteration yet in the brain tumor ependymoma; results offer clues for fighting other cancers.
Gene sequencing project finds new mutations to blame for a majority of brain tumor subtype
The St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project advances understanding of genetic defects underlying childhood low-grade gliomas and identifies promising new drug therapies.
Gene sequencing project identifies potential drug targets in common childhood brain tumor
St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project lifts lid on the most aggressive subtype of medulloblastoma and finds genes that cooperate in tumor development.
Cancer sequencing initiative discovers mutations tied to aggressive childhood brain tumors
St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project provides first evidence linking cancer to mutations in genes involved in DNA organization. (Dr. Suzanne Baker)