Skip to Main Content

Brain Tumor Clinical Trials

Recruiting
HALGG: Hippocampal-Avoidance Using Proton Therapy in Children with Brain Tumors

Full title:

Phase II Study of Hippocampal-Avoidance Using Proton Therapy in Low-Grade Glioma

Study goal:

The main purpose of this study is to find out what happens, good and bad, to memory and learning when the hippocampus is avoided during proton therapy radiation.

Diagnosis:

Low-grade glioma

Age:

At least 6 years old and younger than 22

Recruiting
LOXORET: Phase 1/2 Study of LOXO-292 (Selpercatinib) in Patients with Advanced RET-Altered Solid Tumors or Brain Tumors

Full title:

A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Patients with Advanced Solid or Primary Central Nervous System Tumors 

Study goal:

The main goal of this study is to test the safety of selpercatinib in children and adolescents with solid tumors or brain and spinal cord tumors. Researchers also want to learn how the drug affects cancer in children and the best, most effective dose.

Age:

6 months to 21 years old

Clinical trial categories:

Childhood Cancer Brain Tumors Solid Tumors
Recruiting
Loc3CAR: B7-H3-Specific CAR T-Cell Therapy for Children with Primary CNS Tumors

Full title:

Locoregional Delivery of B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cells for Pediatric Patients with Primary CNS Tumors

Study goal:

The purpose of this study is to find: 1) the largest dose of Loc3CAR T cells that is safe to give patients with B7-H3–positive brain tumors; 2) the side effects of Loc3CAR T cells; 3) the effect Loc3CAR T cells have on brain tumors. This trial will help scientists better understand how the immune system fights this kind of tumor. What we learn from this study could help us create better treatments.

Diagnosis:

Brain tumorsDIPG, DMG

Age:

Up to 21 years old

Clinical trial categories:

Childhood Cancer Brain Tumors Diffuse Intrinsic Pontine Glioma (DIPG)

Diffuse Midline Glioma

Recruiting
PBTC45: MK-3475 in Treating Children with Recurrent, Progressive or Refractory HGGs, DIPGs and Hypermutated Brain Tumors

Full title:

A Safety and Preliminary Efficacy Trial of MK-3475 (Pembrolizumab; anti PD-1) in Children with Recurrent, Progressive or Refractory High-Grade Gliomas (HGG), DIPGs and Hypermutated Brain Tumors

Study goal:

To study the side effects and best dose of MK-3475 (pembrolizumab) and to see how well it works in treating younger patients with high-grade gliomas (brain tumors), diffuse intrinsic pontine gliomas (brain stem tumors), or hypermutated brain tumors that have come back, progressed or have not responded to previous treatment

Diagnosis:

Recurrent, progressive, or refractory high-grade gliomas

Age:

Participant is 1 to 18 years of age

Recruiting
PBTC48: Optune Device in Children with Certain High-Grade Glioma or Ependymoma Brain Tumors

Full title:

Feasibility Trial of Optune for Children with Recurrent or Progressive Supratentorial High-Grade Glioma and Ependymoma

Study goal:

The main purpose of this study is to see if the Optune System is safe to use in children. Researchers also want to find out if children are able to wear the device as instructed.

Diagnosis:

High-grade glioma (HGG), ependymoma

Age:

Between 5 and 21 years old

Recruiting
PBTC49: Phase 1 Trial of Savolitinib in Recurrent, Progressive or Refractory Medulloblastoma, High-Grade Glioma, or Diffuse Intrinsic Pontine Glioma

Full title:

Phase I study of Savolitinib in Recurrent, Progressive or Refractory Medulloblastoma, High-Grade Glioma, or Diffuse Intrinsic Pontine Glioma

Study goal:

 To see if savolitinib is safe and tolerable in children with brain tumors

Age:

Between 5 years old and 21 years old

Recruiting
RT3CR: Proton Therapy for Pediatric Craniopharyngioma

Full title:

A Phase II Trial of Intensity-Modulated Proton Therapy for Incompletely Resected Craniopharyngioma and Observation for Craniopharyngioma After Radical Resection

Study goal:

The main goal of this study is to learn if proton therapy will treat patients with craniopharyngioma brain tumors effectively and reduce side effects compared to traditional forms of radiation therapy.

Diagnosis:

Craniopharyngioma

Age:

21 years old or younger

Clinical trial categories:

Childhood Cancer Craniopharyngioma Brain Tumors
Recruiting
SJ901: Study of Mirdametinib as a Treatment for Children, Adolescents and Young Adults with Low-Grade Glioma

Full title:

SJ901: Phase 1/2 Evaluation of Single Agent Mirdametinib (PD-0325901), a Brain-Penetrant MEK1/2 Inhibitor, for the Treatment of Children, Adolescents, and Young Adults With Low-Grade Glioma

Study goal:

The main goal of this study is to test the experimental drug mirdametinib in hopes of finding a treatment that may be effective against low-grade glioma brain tumors in children, adolescents and young adults.

Diagnosis:

Low-grade glioma

Age:

At least 2 years old and younger than 25 years old.

Recruiting
SJLIFE: Establishment of a Lifetime Cohort of Adults Surviving Childhood Cancer

Full title:

SJLIFE: Establishment of a Lifetime Cohort of Adults Surviving Childhood Cancer

Study goal:

To establish a lifetime group of childhood cancer survivors treated at St. Jude Children’s Research Hospital and to evaluate health outcomes in aging survivors of pediatric cancer

Age:

Participants must be at least 5 years from diagnosis of childhood cancer between 1962-2012, treated and followed at St. Jude

Clinical trial categories:

Childhood Cancer Brain Tumors Leukemia Solid Tumors
Recruiting
SJLTFU: Protocol for Collecting Data on Childhood Cancer Survivors

Full title:

SJLTFU: Protocol for Collecting Data on Childhood Cancer Survivors

Study goal:

To collect information about the effects of childhood cancer and its treatment on the patients who are treated or followed after treatment for childhood cancer at St. Jude Children’s Research Hospital

Clinical trial categories:

Childhood Cancer Brain Tumors Leukemia Solid Tumors
Recruiting
SJPROTON2: Effects of Patient Positioning on Accuracy of Pediatric Proton Therapy

Full title:

Estimating Setup Uncertainty in Pediatric Proton Therapy Using Volumetric Images

Study goal:

The main goal of this study is to collect information about how a patient is positioned and set up for radiation therapy.

Clinical trial categories:

Childhood Cancer Brain Tumors Lymphoma Solid Tumors
Recruiting
SJiMB21: Risk-Based Medulloblastoma Treatment for Infants and Young Children

Full title:

SJiMB21: Phase 2 Study of Molecular and Clinical Risk-Directed Therapy for Infants and Young Children with Newly Diagnosed Medulloblastoma

Study goal:

This study uses a risk-directed approach to find out which types of treatment will work best and have the fewest side effects for infants and children with medulloblastoma.

Diagnosis:

Medulloblastoma

Age:

Birth to 5 years old

Clinical trial categories:

Childhood Cancer Medulloblastoma Brain Tumors
Recruiting
SOCFUN: Social Functioning in Survivors of Pediatric Brain Tumors

Full title:

Components of Social Functioning in Survivors of Pediatric Brain Tumors

Study goal:

Examine the impact of social-cognitive and neurocognitive abilities on social functioning in survivors of pediatric brain tumors

Diagnosis:

Brain tumor

Clinical trial categories:

Childhood Cancer Brain Tumors
Recruiting
U-CHAT: Understanding Communication in Health Care to Achieve Trust

Full title:

Understanding Communication in Health Care to Achieve Trust: A Prospective Longitudinal Investigation of Communication between Pediatric Oncologists, Children/Adolescents with High-Risk Cancer, and their Families at the Stressful Times of Disease Relapse or Progression

Study goal:

To identify recurrent verbal and nonverbal communication techniques employed by pediatric oncologists in the delivery of difficult prognostic information to parents through content analysis of audio recorded conversations between pediatric oncologists and parents of children with high-risk cancer at times of disease re-evaluation

Diagnosis:

Non-therapeutic

Age:

Patients: Age 30 or younger
Parents: Age 18 or older

Clinical trial categories:

Childhood Cancer Solid Tumors Brain Tumors