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Winfred Wang, MD
Winfred C. Wang, MD

Winfred C. Wang, MD

Emeritus, St. Jude Faculty




MD – University of Chicago

Research Interests

  • Sickle cell disease and other hemoglobinopathies
  • Aplastic anemia and other disorders of bone marrow failure
  • Neutropenia and granulocyte colony-stimulating factor (G-CSF)

Selected Publications

Full list of publications

Grace RF, Bianchi P, van Beers EJ, Eber SW, Glader B, Yaish HM, Despotovic JM, Rothman JA, Sharma M, McNaull MM, Fermo E, Lezon-Geyda K, Morton DH, Neufeld EJ, Chonat S, Kollmar N, Knoll CM, Kuo KHM, Kwiatkowski JL, Pospisilova D, Pastore YD, Thompson AA, Newburger PE, Ravindranath Y, Wang WC, Wlodarski MW, Wang H, Holzhauer S, Breakey VR, Kunz J, Sheth S, Rose MJ, Bradeen HA, Neu N, Guo D, Al-Sayegh H, London WB, Gallagher PG, Zanella A, Barcellini W. The clinical spectrum of pyruvate kinase deficiency: Data from the Pyruvate Kinase Deficiency Natural History Study. Blood May 17;131(20):2183-2192, 2018. doi: 10.1182/blood-2017-10-810796. Epub Mar 16, 2018. PMID: 29549173

Estepp JH, Smeltzer MP, Kang G, Li C, Wang WC, Abrams C, Aygun B, Ware RE, Nottage K, Hankins JS.  A clinically meaningful fetal hemoglobin threshold for children with sickle cell anemia during hydroxyurea therapy. Am J Hematol Dec;92(12):1333-1339, 2017. doi: 10.1002/ajh.24906. Epub 2017 Sep 28. PMID: 28913922

Winchell AM, Song R, Loeffler RB, Wang WC, Hankins JS, Helton KA, Hillenbrand CM.  Removal of arterial vessel contributions in susceptibility weighted images for quantification of normalized visible venous volume in children with sickle cell disease. J Healthc Eng 2017:5369385, 2017. doi: 10.1155/2017/5369385. Epub 2017 Aug 28. PMID: 29065618

Ingerski LM, Arnold TL, Banks G, Porter JS, Wang WC. Clinic attendance of youth with sickle cell disease on hydroxyurea treatment. J Pediatr Hematol Oncol Jul;39(5):345-349, 2017. doi: 10.1097/MPH.0000000000000859. PMID: 28562509

Seims AD, VanHouwelingen L, Mead J, Mao S, Loh A, Sandoval JA, Davidoff AM, Wu J, Wang WC, Fernandez-Pineda I. Operative and immediate post-operative differences between multi-port and reduced-port laparoscopic total splenectomy in pediatric patients.  J Laparoendosc Adv Surg Tech 27:206-210, 2017.

Nottage KA, Ware RE, Aygun B, Smeltzer M, Kang G, Moen J, Wang WC, Hankins JS, Helton KJ. Hydroxyurea treatment and MRI/MRA findings in children with sickle cell anemia. Br J Haematol 175:331-338, 2016.

Gammal RS, Crews KR, Haidar CE, Hoffman JM, Baker DK, Barker PJ, Estepp JH, Pei D, Broeckel U, Wang W, Weiss MJ, Relling MV, Hankins J. Pharmacogenetics for safe codeine use in sickle cell disease.  Pediatrics July;138(1), 2016. pii: e20153479. PMCID: PMC4925073

Nottage K, Hankins J, Faughnan L, James D, Richardson J, Christensen R, Kang G, Smeltzer M, Cancio M, Wang W, Anghelescu D.  Addressing challenges of clinical trials in acute pain: The pain management of vaso-occlusive crisis in children and young adults with sickle cell disease study (PMVOC). Clinical Trials 13: 409-416, 2016.

Smeltzer MP, Nolan VG, Yu X, Nottage KA, Davis BA, Yang Y, Wang WC, Gurney JG, Hankins JS.  Birth prevalence of sickle cell trait and sickle cell disease in Shelby County, TN. Pediatr Blood Cancer 63:1054-1059, 2016.

Smeltzer MP, Nolan VG, Yu X, Nottage KA, Wang WC, Hankins JS, Gurney JG.  Distance from an urban sickle center and its effects on routine healthcare management and rates of hospitalization. Hemoglobin 40:10-15, 2016.

Whipple NS, Moreau DAB, Moulds JM, Hankins JS, Wang WC, Nottage KA. Paroxysmal cold hemoglobinuria due to an IgA Donath-Landsteiner antibody. Pediatr Blood Cancer 62:2044-2046, 2015.

Cancio MI, Helton KJ, Schreiber JE, Smeltzer MP, Kang G, Wang WC. Silent cerebral infarcts in very young children with sickle cell anaemia are associated with a higher risk of stroke. Br J Haematol 171:120-129, 2015. 

Hankins JS, Aygun B, Nottage K, Thornburg C, Smeltzer MP, Ware RE, Wang WC. From infancy to adolescence: Fifteen years of continuous treatment with hydroxyurea in sickle cell anemia. Medicine (Baltimore) 93(28):e215, 2014.

Lederman HM, Connolly MA, Kalpatthi R, Ware RE, Wang WC, Luchtman-Jones L, Waclawiw M, Goldsmith JC, Swift A, Casella JF for the BABY HUG investigators. Immunologic effects of hydroxyurea in sickle cell anemia in the phase III clinical trial BABY HUG. Pediatrics 134:686-695, 2014.

Rana S, Houston PE, Wang WC, Iyer RV, Goldsmith J, Casella JF, Reed CK, Rogers ZR, Waclawiw MA, Thompson B for the BABY HUG Investigators.  Hydroxyurea and growth in young children with sickle cell disease.  Pediatrics 134:465-472, 2014.

Nottage KA, Ware RE, Winter B, Smeltzer M, Wang WC, Hankins JS, Dertinger SD, Shulkin B, Aygun B.  Predictors of splenic function preservation in children with sickle cell anemia treated with hydroxyurea.  Eur J Haematol 93:377-383, 2014.

Williams DA, Bennett C, Bertuch A, Bessler M, Coates T, Corey S, Dror Y, Huang J, Lipton J, Olson TS, Reiss UM, Rogers ZR, Sieff C, Vlachos A, Walkovich K, Wang W, Shimamura A.  Diagnosis and treatment of pediatric acquired aplastic anemia (AAA): An initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC).  Pediatr Blood Cancer 61:869-874, 2014.

Daniels CC, Shelton CM, Bass PJ, Wang WC, Suda KJ. Limb swelling in a pediatric sickle cell patient after revaccination with pneumococcal vaccine. Int J Clin Pharm  36(2):261-263, 2014.  published online Dec. 5, 2013 PMID: 24306434

Winchell AM, Taylor BA, Song R, Loeffler RB, Grundlehner P, Hankins JS, Wang WC, Ogg RJ, Hillenbrand CM, Helton KJ. Evaluation of SWI in children with sickle cell disease. Am J Neuroradiol 35:1016-1021, 2014. PMID: 24263696

Nottage KA, Hankins JS, Smeltzer M, Mzayek F, Wang WC, Aygun B, Gurney JG.  Hydroxyurea use and hospitalization trends in a comprehensive pediatric sickle cell program. PLOS ONE 8:e72077, 2013.

Srinivasan A, Wang WC, Gaur A, Smith T, Gu Z, Kang G, Leung W, Hayden R. Prospective detection of respiratory pathogens in children with sickle cell disease and acute respiratory illness. Pediatr Blood Cancer 61:507-511, 2014. published online Oct. 4, 2013

Wang WC, Oyeku SO, Luo Z, Boulet SL, Miller ST, Casella JF, Fish B, Thompson BW, Grosse SD, for the BABY HUG Investigators. Hydroxyurea is associated with lower costs of care of young children with sickle cell anemia. Pediatrics 132:677-683, 2013.

Sheehan VA, Luo A, Flanagan JM, Howard TA, Thompson BW, Wang WC, Kutlar A, Ware RE, for the BABY HUG Investigators. Genetic modifiers of sickle cell anemia in the BABY HUG cohort: Influence on laboratory and clinical phenotypes.  Am J Hematol 88:571-576, 2013.

Estepp JH, Smeltzer MP, Wang WC, Hoehn ME, Hankins JS, Aygun B. Protection from sickle cell retinopathy is associated with elevated HbF levels and hydroxycarbamide use in children. Br J Haematol 161:402-405, 2013.

Kalpatthi R, Thompson B, Lu M, Wang WC, Patel N, Kutlar A, Howard T, Luchtman-Jones L, Miller ST.  Comparison of hematologic measurements between local and central laboratories: Data from the BABY HUG Trial.  Clin Biochem 46:278-281, 2013.

Armstrong FD, Elkin TD, Brown RC, Glass P, Rana S, Casella JF, Kalpatthi RV, Pavlakis S, Mi Z, Wang WC, for the BABY HUG Investigators.  Developmental function in toddlers with sickle cell anemia:  A report from the BABY HUG Trial.  Pediatrics 131:e406-e414, 2013. published online January 6, 2013.

Yates AM, Dedeken L, Smeltzer MP, Lebensburger JD, Wang WC, Robitaille N. Hydroxyurea treatment of children with hemoglobin SC disease. Pediatr Blood Cancer 60:323-325, 2013.

Eckrich MJ, Wang WC, Yang E, Arbogast PG, Morrow A, Dudley JA, Ray WA, Cooper WO. Adherence to transcranial Doppler screening guidelines among children with sickle cell disease. Pediatr Blood Cancer 60:270-274, 2013.

Last update: June 2018