BS – Creighton University (1994)
PhD – University of Minnesota, Twin Cities, Minneapolis, Minnesota (2000)
The goal of our research is to understand how the immune system is regulated so that we can optimize the response to infections and tumors, while preventing harmful autoimmune reactions against normal, healthy tissues.
- Regulation of the immune response in autoimmune diseases including type 1 diabetes and multiple sclerosis.
- Optimizing the immune response against conserved portions of influenza.
- Immune modulation of cartilage homeostasis and osteochondromas.
Harris TL, McGargill MA. Drak2 does not regulate TGF-β signaling in T cells. PloS One 10(5):e0123650, 2015.
Edwards BA, Harris TL, Floersh H, Lukens JR, Zaki MH, Vogel P, Kanneganti TD, Bui JD, McGargill MA. Drak2 is not required for tumor surveillance and suppression. International Immunology 27(3):161-6, 2015.
Keating R, Hertz T, Wehenkel M, Harris TL, Edwards BA, McClaren JL, Brown SA, Surman S, Wilson ZS, Bradley P, Hurwitz J, Chi H, Doherty PC, Thomas PG, McGargill MA. The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus. Nat Immunol 14(12):1266-76, 2013.
Anand PK, Tait SW, Lamkanfi M, Amer AO, Nunez G, Pagès G, Pouysségur J, McGargill MA, Green DR, Kanneganti TD. TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation. J Biol Chem 286:42981-91, 2011.
Shaw PJ, Barr MJ, Lukens JR, McGargill MA, Chi H, Mak TW, Kanneganti TD. Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity. Immunity 34:75-84, 2011.
Kerdiles YM, Stone EL, Beisner DL, McGargill MA, Ch'en IL, Stockmann C, Katayama CD, Hedrick SM. Foxo transcription factors control regulatory T cell development and function. Immunity 33:890-904, 2010.
Shaw PJ, Lukens JR, Burns S, Chi H, McGargill MA, Kanneganti TD. Cutting Edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis. Journal of Immunology 184:4610-4, 2010.
McGargill MA, Ch’en IL, Katayama CD, Pages G, Pouyssegur, J, Hedrick SM. Cutting Edge: Extracellular signal-related kinase is not required for negative selection of developing T cells.Journal of Immunology 183:4838-42, 2009.
Hayashi T, Gray C, Chan M, Tawatao R, Lisa Ronacher L, McGargill MA, Datta S, Carson D, Corr M. Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7. Proceedings of the National Academy of Sciences 106:2764-9, 2009.
McGargill MA, Choy C, Wen BG, Hedrick SM. Drak2 regulates the survival of activated T cells and is required for organ-specific autoimmune disease. Journal of Immunology 20181:7593-7605, 2008.
Wang S, Welte T, McGargill M, Town T, Thompson J, Anderson JF, Flavell RA, Fikrig E, Hedrick SM, Wang T. Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis. Journal of Immunology 181:2084-91, 2008.
McGargill MA, Sharp LL, Bui JD, Hedrick SM, Calbo S. Active Ca2 /calmodulin-dependent protein kinase IIgammaB impairs positive selection of T cells by modulating TCR signaling. Journal of Immunology 175:656-64, 2005.
McGargill MA, Wen BG, Walsh CM, Hedrick SM. A deficiency in Drak2 results in a T cell hypersensitivity, and an unexpected resistance to autoimmunity. Immunity 6:781-91, 2004.
McGargill MA, Mayerova D, Stefanski HE, Koehn B, Parke EA, Jameson SJ, Panoskaltsis-Mortari A, Hogquist KA. A spontaneous CD8 T cell dependent autoimmune disease to an antigen expressed under the Human Keratin 14 Promoter. Journal of Immunology 169:2141-2147, 2002.
McGargill MA, Derbinski J, Hogquist KA. Receptor editing in developing T cells. Nature Immunology 1:336-341, 2000.
McGargill MA, Hogquist KA. T cell receptor editing. Immunology Letters 75:27-31, 2000.
McGargill MA, Hogquist KA. Antigen-induced co-receptor downregulation on thymocytes is not a result of apoptosis. Journal of Immunology 162:1237-1245, 1999.
Hogquist KA, Tomlinson AJ, Kieper WC, McGargill MA, Naylor S, Jameson SC. Identification of a naturally occurring ligand for thymic positive selection. Immunity 6(4):389-399, 1997.
Last update: June 2015