Winfred Wang, MD
Winfred C. Wang, MD

Winfred C. Wang, MD

Member, St. Jude Faculty




MD – University of Chicago

Research Interests

  • Sickle cell disease and other hemoglobinopathies
  • Aplastic anemia and other disorders of bone marrow failure
  • Neutropenia and granulocyte colony-stimulating factor (G-CSF)

Sickle Cell Scholars

Selected Publications

Hankins JS, Aygun B, Nottage K, Thornburg C, Smeltzer MP, Ware RE, Wang WC. From Infancy to Adolescence: Fifteen Years of Continuous Treatment With Hydroxyurea in Sickle Cell Anemia. Medicine (Baltimore) 93(28):e215, 2014.

Lederman HM, Connolly MA, Kalpatthi R, Ware RE, Wang WC, Luchtman-Jones L, Waclawiw M, Goldsmith JC, Swift A, Casella JF. Immunologic Effects of Hydroxyurea in Sickle Cell Anemia. Pediatrics 134(4):686-95, 2014.

Kalpatthi R, Thompson B, Lu M, Wang WC, Patel N, Kutlar A, Howard T, Luchtman-Jones L, Miller ST. Comparison of hematologic measurements between local and central laboratories: Data from the BABY HUG Trial. Clin Biochem 46:278-281, 2013.

Yates AM, Dedeken L, Smeltzer MP, Lebensburger JD, Wang WC, Robitaille N. Hydroxyurea treatment of children with hemoglobin SC disease. Pediatr Blood Cancer 60:323-325, 2013.

Eckrich MJ, Wang WC, Yang E, Arbogast PG, Morrow A, Dudley JA, Ray WA, Cooper WO. Adherence to transcranial Dopper screening guidelines among children with sickle cell disease. Pediatr Blood Cancer 60:270-274, 2013.

Thornburg CD, Files BA, Luo Z, Miller ST, Kalpatthi R, Iyer R, Seaman P, Lebensburger J, Alvarez O, Thompson B, Ware RE, Wang WC, for the BABY HUG Investigators. Impact of hydroxyurea on clinical events in the BABY HUG Trial. Blood 120:4304-4310, 2012.

Williams-Hooker R, Olivi S, Smeltzer MP, Wang WC. Health-related quality of life is associated with hemoglobin level in children with sickle cell anemia. J Blood Disorders Trans 3(4):129, 2012. doi:10.4172/2155-9864.1000129.

Alvarez O, Miller ST, Wang WC, Luo Z, McCarville MB, Schwartz GJ, Thompson B, Howard T, Iyer RV, Rana SR, Rogers ZR, Sarnaik SA, Thornburg CD, Ware RE and the BABY HUG Investigators. Effect of hydroxyurea treatment on renal function parameters: Results from the multi-center placebo-controlled BABY HUG clinical trial for infants with sickle cell anemia. Pediatr Blood Cancer 59:668-674, 2012.

Shete M, Thompson JW, Naidu SI, Stocks RMS, Wang WC. Otolaryngologic manifestations in children with chronic neutropenia. Int J Pediatr Otorhinolaryngol 76:392-395, 2012.

Miller ST, Rey K, He J, Flanagan J, Fish BJ, Rogers ZR, Wang WC, Ware RE, for the BABY HUG Investigators. Massive accidental overdose of hydroxyurea in a young child with sickle cell anemia. Pediatr Blood Cancer 59:170-172, 2012.

Lebensburger JD, Miller ST, Howard TH, Casella JF, Brown RC, Lu M, Iyer RV, Sarnaik S, Rogers ZR, Wang WC, for the BABY HUG Investigators. Influence of severity of anemia on clinical findings in infants with sickle cell anemia: Analysis from the BABY HUG Study. Pediatr Blood Cancer 59:675-678, 2012.

Zou P, Helton KJ, Smeltzer M, Li CS, Conklin HM, Gajjar A, Wang WC, Ware RE, Ogg RJ. Hemodynamic responses to visual stimulation in children with sickle cell anemia. Brain Imaging Behav 5:295-306, 2011.

Quinn CT, Stuart MJ, Kesler K, Ataga KI, Wang WC, Styles L, Smith-Whitley K, Wun T, Raj A, Hsu LL, Krishnan S, Kuypers FA, Setty Y, Rhee S, Key NS, Buchanan GR CN - on Behalf of the Investigators of the Comprehensive Sickle Cell Centers. Tapered oral dexamethasone for the acute chest syndrome of sickle cell disease. Br J Haematol 155:263-267, 2011.

McCarville MB, Luo Z, Huang X, Rees RC, Rogers ZR, Miller ST, Thompson B, Kalpatthi R, Wang WC, the BABY HUG Investigators. Abdominal ultrasound with scintigraphic and clinical correlates in infants with sickle cell anemia: baseline data from the BABY HUG trial. AJR Am J Roentgenol 196(6):1399-1404, 2011.

Wang WC, Ware RE, Miller ST, Iyer RV, Casella JF, Minniti CP, Rana S, Thornburg CD, Rogers ZR, Kalpatthi RV, Barredo JC, Brown RC, Sarnaik SA, Howard TH, Wynn LW, Kutlar A, Armstrong FD, Files BA, Goldsmith JC, Waclawiw MA, Huang X, Thompson BW, CN - BABY HUG investigators. Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG). Lancet 377(9778):1663-72, 2011.

Rogers ZR, Wang WC, Luo Z, Iyer RV, Shalaby-Rana E, Dertinger SD, Shulkin BL, Miller JH, Files B, Lane PA, Thompson BW, Miller ST, Ware RE. Biomarkers of splenic function in infants with sickle cell anemia: baseline data from the BABY HUG Trial. Blood 117(9):2614-17, 2011.

Wang WC. Sickle-cell disease and compromised cognition. Pediatr Blood Cancer 56(5):705-6, 2011.

Wang W, Brugnara C, Snyder C, Wynn L, Rogers Z, Kalinyak K, Brown C, Qureshi A, Bigelow C, Neumayr L, Smith-Whitley K, Chui DH, Delahunty M, Woolson R, Steinberg M, Telen M, Kesler K. The effects of hydroxycarbamide and magnesium on haemoglobin SC disease: results of the multi-centre CHAMPS trial. Br J Haematol 152(6):771-6, 2011.

Aygun B, Parker J, Freeman MB, Stephens AL, Smeltzer MP, Wu S, Hankins JS, Wang WC. Neurocognitive screening with the Brigance Preschool screen-II in 3-year-old children with sickle cell disease. Pediatr Blood Cancer November 11, 2010.

Wynn L, Miller S, Faughnan L, Luo Z, Debenham E, Adix L, Fish B, Hustace T, Kelly T, Macdermott M, Marasciulo J, Martin B, McDuffie J, Murphy M, Rackoff B, Reed C, Seaman P, Thomas G, Wang W. Recruitment of infants with sickle cell anemia to a phase III trial: data from the BABY HUG study.Contemp Clin Trials 31(6):558-63, 2010.

Fowler KT, Williams R, Mitchell CO, Levy MC, Pope LF, Smeltzer MP, Wang WC. Dietary water and sodium intake of children and adolescents with sickle cell anemia. J Pediatr Hematol Oncol May 24, 2010.

Warren MD, Arbogast PG, Dudley JA, Kaltenbach L, Ray WA, Wang WC, Cooper WO. Adherence to prophylactic antibiotic guidelines among Medicaid infants with sickle cell disease. Arch Pediatr Adolesc Med 164(3):298-299, 2010.

Hankins JS, McCarville MB, Loeffler RB, Smeltzer MP, Onciu M, Hoffer FA, Li C-S, Wang WC, Ware RE, Hillenbrand CM. R2* magnetic resonance imaging of the liver in patients with iron overload. Blood 113:4853-9, 2009.

Hassell K, Pace B, Wang W, Kulkarni R, Luban N, Johnson CS, Eckman J, Lane P, Woods W. Sickle cell disease summit: From clinical and research disparity to action. Am J Hematol 84:39-45, 2009.

Helton KJ, Paydar A, Glass J, Weirich EM, Hankins J, Li C-S, Smeltzer MP, Wang WC, Ware RE, Ogg RJ. Arterial spin-labeled perfusion combined with segmentation techniques to evaluate cerebral blood flow in white and gray matter of children with sickle cell anemia. Pediatr Blood Cancer 52:85-91, 2009.

Wang WC. Sickle cell anemia and other sickling syndromes (chapter 37). In: Greer JP, Foerster J, Rodgers GM, Paraskevas F, Glader BE, eds. Wintrobe's Clinical Hematology, 12th edition. Philadelphia: Lippincott Williams and Wilkins 2008, pp. 1038-82.

Wang WC. The pharmacotherapy of sickle cell disease. Expert Opin Pharmacother 9:3083-3094, 2008.

Wang WC, Pavlakis SG, Helton KJ, McKinstry RC, Casella JF, Adams RJ, Rees RC, for the BABY HUG Investigators. MRI abnormalities in the brain in one year-old children with sickle cell anemia.Pediatr Blood Cancer 51:643-6, 2008.

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Lebensburger J, Esbenshade A, Blakely M, Hankins J, Wang W. Biloma and pneumobilia in sickle cell disease. Pediatr Blood Cancer 51:288-305, 2008.

Hankins JS, Fortner G, McCarville B, Smeltzer M, Wang WC, Li C-S, Ware RE. The natural history of conditional transcranial Doppler flow velocities in children with sickle cell anemia. Br J Haematol 142:94-9, 2008.

McCarville MB, Goodin GS, Fortner G, Day S, Li C-S., Adams, R, Wang W.Evaluation of a comprehensive transcranial doppler screening program for children with sickle cell anemia. Pediatr Blood Cancer 50(4):818-21, 2008.

Shankar SM, Arbogast PG, Mitchel E, Ding H, Wang WC, Griffin MR. Impact of access to comprehensive care on utilization of healthcare services among children with sickle cell disease.Pediatr Blood Cancer 50:66-71, 2008.

Hankins J, Helton K, McCarville B, Li C-S, Wang W, Ware R. Preservation of spleen and brain function in children with sickle cell anemia treated with hydroxyurea. Pediatr Blood Cancer 50:293-7, 2008.

Last update: January 2015